比较前列腺癌放疗前后的痛苦评分。
Comparison of Distress Scores Before and After Radiotherapy for Prostate Cancer.
机构信息
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Medical Practice for Radiotherapy and Radiation Oncology, Hannover, Germany.
出版信息
In Vivo. 2023 Sep-Oct;37(5):2173-2177. doi: 10.21873/invivo.13316.
BACKGROUND/AIM: Prostate cancer patients undergoing radiotherapy (RT) may experience distress. This study evaluated the course of distress during RT.
PATIENTS AND METHODS
Four distress characteristics were analyzed for change of distress in 136 patients irradiated for prostate cancer, including age, Karnofsky performance score, intent of RT, and previous RT.
RESULTS
Mean distress scores were 4.3 (±2.9) at baseline and 4.2 (±2.7) at the end of RT. Associations with increased distress were found for KPS >80 (p<0.001) and curative intent RT (p=0.072). When evaluating increased distress as binary variable (yes vs. no), KPS >80 was significant on univariable (p<0.001) and multivariable (p=0.016) analyses. In patients with baseline scores ≤5 points, KPS >80 was associated with mean change of distress (p=0.009) and increased distress (p=0.029).
CONCLUSION
Many patients receiving RT for prostate cancer do not experience increased distress during their treatment course. Patients at higher risk of increased distress may require early psychological assistance.
背景/目的：接受放疗（RT）的前列腺癌患者可能会感到痛苦。本研究评估了 RT 过程中痛苦的变化过程。
患者和方法
对 136 名接受前列腺癌放疗的患者的 4 种痛苦特征进行分析，包括年龄、卡诺夫斯基表现评分、RT 意图和之前的 RT。
结果
基线时的平均痛苦评分为 4.3（±2.9），RT 结束时为 4.2（±2.7）。与痛苦增加相关的因素包括 KPS>80（p<0.001）和根治性 RT（p=0.072）。当评估增加的痛苦为二进制变量（是/否）时，KPS>80 在单变量（p<0.001）和多变量（p=0.016）分析中均有显著意义。在基线评分≤5 分的患者中，KPS>80 与痛苦的平均变化（p=0.009）和痛苦增加（p=0.029）相关。
结论
许多接受前列腺癌 RT 的患者在治疗过程中没有经历痛苦增加。有更高痛苦增加风险的患者可能需要早期的心理援助。
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