Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan
Anticancer Res. 2023 Sep;43(9):4221-4227. doi: 10.21873/anticanres.16614.
BACKGROUND/AIM: F-fluorodeoxyglucose (FDG) is known to accumulate in the liver. We investigated whether accumulation of FDG was correlated with the degree of liver fibrosis and the grade of necro-inflammatory activity.
This retrospective study included 35 patients who underwent FDG-positron emission tomography (PET)/computed tomography (CT) before liver surgery. On fusion images of CT and PET, by placing regions of interest on the lateral, anterior and posterior segments of the liver and the aorta, the standardized uptake value (SUV) mean, and SUV normalized by lean body mass (SUL) mean of the liver were measured, and the ratio SUVmean liver/SUVmean aorta was calculated. According to the New Inuyama Classification, subjects were classified into three groups based on the grade of liver-fibrosis degree, i.e., F0, F1+F2 and F3+F4, and into three groups based on the grade of necro-inflammatory activity, i.e., A0, A1 and A2. Each of the above parameters was then compared among the groups using a Tukey test.
Average SULmean liver values of the F0, F1+F2 and F3+F4 groups were 1.573±0.211, 1.845±0.220 and 1.716±0.119, respectively. The SULmean liver of the F1+F2 group was significantly higher than that of the F0 group (p=0.0296). No significant difference was observed for the other two parameters. None of the parameters exhibited significant difference among the A0, A1, and A2 groups.
FDG accumulation in the liver may be increased in the early stage of liver fibrosis. SULmean liver could be used to determine the necessity for therapeutic intervention in chronic liver disease.
背景/目的：氟代脱氧葡萄糖（FDG）已知在肝脏中积聚。我们研究了 FDG 的积聚是否与肝纤维化程度和坏死性炎症活动程度相关。
这项回顾性研究纳入了 35 名在肝外科手术前接受 FDG 正电子发射断层扫描（PET）/计算机断层扫描（CT）的患者。在 CT 和 PET 的融合图像上，通过在肝脏的外侧、前侧和后侧以及主动脉上放置感兴趣区域，测量肝脏的标准化摄取值（SUV）平均值和按瘦体重（SUL）标准化的 SUV 平均值，并计算 SUVmean 肝脏/SUVmean 主动脉的比值。根据新入谷分类，根据肝纤维化程度的等级将受试者分为 F0、F1+F2 和 F3+F4 三组，根据坏死性炎症活动的等级分为 A0、A1 和 A2 三组。然后使用 Tukey 检验比较各组之间的上述参数。
F0、F1+F2 和 F3+F4 组的平均 SULmean 肝脏值分别为 1.573±0.211、1.845±0.220 和 1.716±0.119。F1+F2 组的 SULmean 肝脏明显高于 F0 组（p=0.0296）。其他两个参数没有差异。三个参数在 A0、A1 和 A2 组之间均无差异。
FDG 在肝脏中的积聚可能在肝纤维化的早期阶段增加。SULmean 肝脏可用于确定慢性肝病治疗干预的必要性。
