眼底黄色斑点症和广泛黄斑萎缩伴假性玻璃膜疣之间的视网膜萎缩进展的眼底自发荧光
Fundus autofluorescence of retinal atrophy progression between fundus flavimaculatus and extensive macular atrophy with pseudo-drusen.
机构信息
Department of Ophthalmology, University of Paris Est-Créteil, Créteil, France.
ONO Clinique de l'Oeil SA, Onex, Switzerland.
出版信息
Eur J Ophthalmol. 2024 Mar;34(2):524-528. doi: 10.1177/11206721231199635. Epub 2023 Aug 30.
OBJECTIVE
To analyze the progression of macular atrophy in Fundus Flavimaculatus (FFM) versus Extensive Macular Atrophy with Pseudo-drusen (EMAP), using Spectralis® RegionFinder™ tool.
METHODS
Retrospective review of patients diagnosed with FFM and EMAP. Ophthalmic imaging features were reviewed by retina specialists for each patient in both eyes. The atrophic zones were measured on fundus autofluorescence acquisitions using the RegionFinder™ tool.
RESULTS
FFM group included 16 eyes of 8 patients, whose mean age was 61.42 ± 10.76 years, with a mean 4.54 ± 2.73 years of follow-up. EMAP group contained 16 eyes of 8 patients, whose mean age was 67.81 ± 3.03 years ( = 0.12), with a mean 3.62 ± 2.49 years of follow-up ( = 0.63). The atrophy progression rates were 3.73 ± 6.75 and 0.70 ± 0.98 mm/year, for EMAP and FFM respectively. The yearly rate of progression of the atrophic areas in EMAP was 5.3 times higher than in FFM (mm/year) ( = 0.03).
CONCLUSION
The progression of the atrophy in eyes with Extensive Macular Atrophy with Pseudo-drusen (EMAP) is significantly more rapid than in eyes with Fundus Flavimaculatus (FFM).
目的
利用 Spectralis® RegionFinder™ 工具分析眼底黄色斑点症（FFM）与假性玻璃膜疣广泛型黄斑萎缩（EMAP）的黄斑萎缩进展情况。
方法
回顾性分析诊断为 FFM 和 EMAP 的患者。由视网膜专家对每位患者双眼的眼科图像特征进行评估。使用 RegionFinder™ 工具在眼底自发荧光采集图像上测量萎缩区。
结果
FFM 组包括 8 名患者的 16 只眼，平均年龄为 61.42±10.76 岁，平均随访时间为 4.54±2.73 年。EMAP 组包括 8 名患者的 16 只眼，平均年龄为 67.81±3.03 岁（=0.12），平均随访时间为 3.62±2.49 年（=0.63）。EMAP 和 FFM 的萎缩进展率分别为 3.73±6.75 和 0.70±0.98mm/年。EMAP 中萎缩区每年的进展速度比 FFM 快 5.3 倍（mm/年）（=0.03）。
结论
与眼底黄色斑点症（FFM）相比，假性玻璃膜疣广泛型黄斑萎缩（EMAP）的萎缩进展速度明显更快。
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