Jiang Yan, Yuan Jing-Chuan, Song Ge, Zhang Xu-Hui, Miao Sui-Bing, Wu Xiao-Hua
The Center for Reproductive Medicine and Infertility, The Fourth Hospital of Shijiazhuang, Shijiazhuang Obstetrics and Gynecology Hospital Affiliated to Hebei Medical University, Key Laboratory of Maternal and Fetal Medicine of Hebei, Shijiazhuang, Hebei 050011, P.R. China.
Biomed Rep. 2023 Aug 9;19(4):66. doi: 10.3892/br.2023.1648. eCollection 2023 Oct.
Early rescue intracytoplasmic sperm injection (Re-ICSI) can prevent total fertilization failure (TFF) during conventional fertilization (IVF). However, the implantation rate of Re-ICSI embryos is lower than that of direct ICSI during fresh embryo transfer (ET). The aim of the present study was to investigate the effect of frozen ET (FET) after Re-ICSI. In the present retrospective study, primary infertility patients that underwent the first Re-ICSI and ICSI treatment, were studied. The clinical pregnancy rate, implantation rate, ectopic pregnancy, abortion rate and live birth rate were analyzed between the Re-ICSI and ICSI groups in fresh ET and FET cycles. The average age of patients between Re-ICSI and ICSI groups in fresh ET and FET cycles was (29.0±3.2 vs. 29.1±3.1, and 29.1±3.3 vs. 28.9±3.0), respectively (P>0.05). Compared with ICSI embryos, the clinical pregnancy, implantation and live birth rates of Re-ICSI embryos were lower in fresh ET cycles. By contrast, there were no significant differences in the pregnancy, implantation and live birth rates between the Re-ICSI and ICSI embryos during the FET cycles. Re-ICSI coupled with FET may overcome the impaired outcomes in fresh ET.
早期挽救性卵胞浆内单精子注射（Re-ICSI）可预防常规受精（IVF）过程中的完全受精失败（TFF）。然而，在新鲜胚胎移植（ET）期间，Re-ICSI胚胎的着床率低于直接ICSI胚胎。本研究的目的是探讨Re-ICSI后冷冻胚胎移植（FET）的效果。在本回顾性研究中，对接受首次Re-ICSI和ICSI治疗的原发性不孕患者进行了研究。分析了新鲜ET周期和FET周期中Re-ICSI组与ICSI组之间的临床妊娠率、着床率、异位妊娠率、流产率和活产率。新鲜ET周期和FET周期中Re-ICSI组与ICSI组患者的平均年龄分别为（29.0±3.2对29.1±3.1，以及29.1±3.3对28.9±3.0）（P>0.05）。与ICSI胚胎相比，新鲜ET周期中Re-ICSI胚胎的临床妊娠率、着床率和活产率较低。相比之下，FET周期中Re-ICSI胚胎与ICSI胚胎的妊娠率、着床率和活产率无显著差异。Re-ICSI联合FET可能克服新鲜ET中受损的结局。
