• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

内皮细胞衰老的代谢调控

Metabolic regulation of endothelial senescence.

作者信息

Le Nhat-Tu

机构信息

Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States.

出版信息

Front Cardiovasc Med. 2023 Aug 15;10:1232681. doi: 10.3389/fcvm.2023.1232681. eCollection 2023.

DOI:10.3389/fcvm.2023.1232681
PMID:37649668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10464912/
Abstract

Endothelial cell (EC) senescence is increasingly recognized as a significant contributor to the development of vascular dysfunction and age-related disorders and diseases, including cancer and cardiovascular diseases (CVD). The regulation of cellular senescence is known to be influenced by cellular metabolism. While extensive research has been conducted on the metabolic regulation of senescence in other cells such as cancer cells and fibroblasts, our understanding of the metabolic regulation of EC senescence remains limited. The specific metabolic changes that drive EC senescence are yet to be fully elucidated. The objective of this review is to provide an overview of the intricate interplay between cellular metabolism and senescence, with a particular emphasis on recent advancements in understanding the metabolic changes preceding cellular senescence. I will summarize the current knowledge on the metabolic regulation of EC senescence, aiming to offer insights into the underlying mechanisms and future research directions.

摘要

内皮细胞（EC）衰老日益被认为是血管功能障碍以及包括癌症和心血管疾病（CVD）在内的与年龄相关的病症和疾病发展的重要因素。已知细胞衰老的调节受细胞代谢的影响。虽然已经对癌细胞和成纤维细胞等其他细胞中衰老的代谢调节进行了广泛研究，但我们对内皮细胞衰老的代谢调节的理解仍然有限。驱动内皮细胞衰老的具体代谢变化尚未完全阐明。本综述的目的是概述细胞代谢与衰老之间的复杂相互作用，特别强调在理解细胞衰老之前的代谢变化方面的最新进展。我将总结关于内皮细胞衰老代谢调节的当前知识，旨在深入了解潜在机制和未来研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/ab41801bfa5f/fcvm-10-1232681-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/ed7821857587/fcvm-10-1232681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/a183ad6a47a9/fcvm-10-1232681-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/0915317008d7/fcvm-10-1232681-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/b9a6acc42f44/fcvm-10-1232681-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/6f5570a7e4bf/fcvm-10-1232681-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/41c9dbb41839/fcvm-10-1232681-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/83823a661590/fcvm-10-1232681-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/ab41801bfa5f/fcvm-10-1232681-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/ed7821857587/fcvm-10-1232681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/a183ad6a47a9/fcvm-10-1232681-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/0915317008d7/fcvm-10-1232681-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/b9a6acc42f44/fcvm-10-1232681-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/6f5570a7e4bf/fcvm-10-1232681-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/41c9dbb41839/fcvm-10-1232681-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/83823a661590/fcvm-10-1232681-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59da/10464912/ab41801bfa5f/fcvm-10-1232681-g008.jpg

相似文献

1
Metabolic regulation of endothelial senescence.内皮细胞衰老的代谢调控
Front Cardiovasc Med. 2023 Aug 15;10:1232681. doi: 10.3389/fcvm.2023.1232681. eCollection 2023.
2
Divergent mechanisms of metabolic dysfunction drive fibroblast and T-cell senescence.代谢功能障碍的不同机制驱动成纤维细胞和 T 细胞衰老。
Ageing Res Rev. 2018 Nov;47:24-30. doi: 10.1016/j.arr.2018.06.001. Epub 2018 Jun 15.
3
Endothelial Cell Senescence Exacerbates Pulmonary Fibrosis Potentially Through Accelerated Endothelial to Mesenchymal Transition.内皮细胞衰老通过加速内皮细胞向间充质转化可能加剧肺纤维化。
Kobe J Med Sci. 2021 Nov 2;67(3):E84-E91.
4
Senescence mechanisms and targets in the heart.心脏衰老的机制和靶点。
Cardiovasc Res. 2022 Mar 25;118(5):1173-1187. doi: 10.1093/cvr/cvab161.
5
Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights.癌症治疗后的早衰与心血管疾病：机制洞察
Front Cardiovasc Med. 2023 Sep 14;10:1212174. doi: 10.3389/fcvm.2023.1212174. eCollection 2023.
6
The Role of MicroRNAs in Endothelial Cell Senescence.微小 RNA 在血管内皮细胞衰老中的作用。
Cells. 2022 Mar 31;11(7):1185. doi: 10.3390/cells11071185.
7
Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors.癌症幸存者动脉粥样硬化发展背后可能的分子机制。
Front Cardiovasc Med. 2023 Jun 2;10:1186679. doi: 10.3389/fcvm.2023.1186679. eCollection 2023.
8
Metabolic regulation of immune cells in proinflammatory microenvironments and diseases during ageing.衰老过程中促炎微环境及疾病中免疫细胞的代谢调控。
Ageing Res Rev. 2020 Dec;64:101165. doi: 10.1016/j.arr.2020.101165. Epub 2020 Sep 6.
9
Endothelial cell senescence in aging-related vascular dysfunction.衰老相关血管功能障碍中的内皮细胞衰老。
Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1802-1809. doi: 10.1016/j.bbadis.2018.08.008. Epub 2018 Aug 18.
10
The metabolic roots of senescence: mechanisms and opportunities for intervention.衰老的代谢根源：干预的机制和机会。
Nat Metab. 2021 Oct;3(10):1290-1301. doi: 10.1038/s42255-021-00483-8. Epub 2021 Oct 18.

引用本文的文献

1
Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development.衰老和流体剪切应力对血管内皮代谢及动脉粥样硬化发展的影响。
J Biomed Sci. 2025 Sep 1;32(1):83. doi: 10.1186/s12929-025-01177-z.
2
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.伴侣蛋白介导的自噬通过双重机制来平衡过早衰老和衰老细胞溶解，以预防椎间盘退变。
Bone Res. 2025 Jun 12;13(1):62. doi: 10.1038/s41413-025-00441-0.
3
Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF-β Pathway Inhibition.

本文引用的文献

1
Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors.癌症幸存者动脉粥样硬化发展背后可能的分子机制。
Front Cardiovasc Med. 2023 Jun 2;10:1186679. doi: 10.3389/fcvm.2023.1186679. eCollection 2023.
2
The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation.NAD+ 分子在衰老发展和预防慢性与年龄相关疾病中的核心作用：NAD+ 调节策略。
Int J Mol Sci. 2023 Feb 3;24(3):2959. doi: 10.3390/ijms24032959.
3
A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity.
马凡综合征中的内皮细胞衰老：TGF-β信号通路抑制的发病机制及治疗潜力
J Am Heart Assoc. 2025 May 6;14(9):e037826. doi: 10.1161/JAHA.124.037826. Epub 2025 Apr 16.
4
In Vitro Modeling of Vascular Senescence.血管衰老的体外建模
Methods Mol Biol. 2025;2906:271-279. doi: 10.1007/978-1-0716-4426-3_16.
5
New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death.动脉粥样硬化的新曙光：血管内皮细胞衰老与死亡。
Int J Mol Sci. 2023 Oct 13;24(20):15160. doi: 10.3390/ijms242015160.
一种新的 AMPK 同工型通过促进膜流动性非细胞自主地介导葡萄糖限制诱导的长寿。
Nat Commun. 2023 Jan 18;14(1):288. doi: 10.1038/s41467-023-35952-z.
4
NAD Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease.NAD 代谢与早衰和慢性肾脏病中的干预措施。
Cells. 2022 Dec 21;12(1):21. doi: 10.3390/cells12010021.
5
Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics.血管疾病中的血管内皮衰老：衰老治疗学的现有认识和未来机遇。
Exp Mol Med. 2023 Jan;55(1):1-12. doi: 10.1038/s12276-022-00906-w. Epub 2023 Jan 4.
6
Bioreactor Expansion Reconfigures Metabolism and Extracellular Vesicle Biogenesis of Human Adipose-derived Stem Cells In Vitro.生物反应器扩增在体外重新配置人脂肪来源干细胞的代谢和细胞外囊泡生物发生
Biochem Eng J. 2022 Dec 15;188. doi: 10.1016/j.bej.2022.108711. Epub 2022 Nov 2.
7
Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells.抑制谷氨酰胺分解可恢复衰老干细胞中的线粒体功能。
Cell Rep. 2022 Nov 29;41(9):111744. doi: 10.1016/j.celrep.2022.111744.
8
Radiation therapy induces immunosenescence mediated by p90RSK.放射治疗会诱导由p90RSK介导的免疫衰老。
Front Cardiovasc Med. 2022 Nov 7;9:988713. doi: 10.3389/fcvm.2022.988713. eCollection 2022.
9
The Role of NAD+ in Regenerative Medicine.NAD+ 在再生医学中的作用。
Plast Reconstr Surg. 2022 Oct 1;150(4 Suppl):41S-48S. doi: 10.1097/PRS.0000000000009673. Epub 2021 Sep 28.
10
Flow pattern-dependent mitochondrial dynamics regulates the metabolic profile and inflammatory state of endothelial cells.流型依赖性线粒体动力学调节内皮细胞的代谢特征和炎症状态。
JCI Insight. 2022 Sep 22;7(18):e159286. doi: 10.1172/jci.insight.159286.