Minz Pradeep, Oroan Asha, Kujur Anit, Paswan Dilip K, Nag Alka R
Department of Physiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Department of Biochemistry, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
J Family Med Prim Care. 2023 Jul;12(7):1394-1398. doi: 10.4103/jfmpc.jfmpc_2307_22. Epub 2023 Jul 14.
Epilepsy is a syndrome of various neurological disorders. Idiosyncratic hepatotoxicity is a rare adverse effect associated with antiepileptic drugs (AED) therapy. Antiepileptic drugs may produce hepatic injury as part of a more widespread hypersensitivity reaction. Laboratory monitoring of asymptomatic effects may allow for the early detection of hepatotoxicity. So the present prospective longitudinal study was carried out to determine the effects of Anticonvulsant drug on liver enzymes among Epileptic Children.
A prospective observational study was conducted among children with seizure disorder attending Paediatric outdoor patient Department of Rajendra Institute of Medical Sciences, Ranchi from February 2014 to October 2015. 50 children with newly diagnosed or untreated seizure disorder were included in case and 50 children of both sexes with same age group as cases were selected as control who did not have seizure. Children with age ranging from 2-10 years were included by consecutive sampling technique. Data was analysed using Statistical Package for Social Sciences (SPSS) software version 25(IBM Corp., Armonk, NY, USA). Paired t test was used to compare the mean values of liver enzymes amongst the children."-value" was considered to be non - significant if found ≥ 0.05 and significant if -value was found to be <0.05.
In the present study there was no significant alteration of hepatic profile after treatment with valproate except serum alkaline phosphatase which was increased from the initial value than control group and was statistically significantly with value of less than 0.05.
We concluded that these Antiepileptic drugs are safe to use in children up to 1 year.
癫痫是一种由多种神经系统疾病引起的综合征。特异质性肝毒性是抗癫痫药物（AED）治疗中罕见的不良反应。抗癫痫药物可能作为更广泛的超敏反应的一部分导致肝损伤。对无症状影响进行实验室监测可能有助于早期发现肝毒性。因此，本前瞻性纵向研究旨在确定抗惊厥药物对癫痫儿童肝酶的影响。
2014年2月至2015年10月，在兰契市拉金德拉医学科学研究所儿科门诊就诊的癫痫患儿中进行了一项前瞻性观察研究。纳入50例新诊断或未治疗的癫痫患儿作为病例组，选取50例年龄与病例组相同的非癫痫患儿作为对照组。采用连续抽样技术纳入年龄在2至10岁之间的儿童。使用社会科学统计软件包（SPSS）25版（美国纽约州阿蒙克市IBM公司）进行数据分析。采用配对t检验比较儿童肝酶的平均值。如果“P值”≥0.05，则认为差异无统计学意义；如果P值<0.05，则认为差异有统计学意义。
在本研究中，除血清碱性磷酸酶外，丙戊酸盐治疗后肝脏指标无显著变化，血清碱性磷酸酶较初始值升高，高于对照组，且差异有统计学意义，P值小于0.05。
我们得出结论，这些抗癫痫药物在1岁以下儿童中使用是安全的。
