Zafar Azra, Shahid Rizwana, Nazish Saima, Aljaafari Danah, Alkhamis Fahd Ali, Alsalman Sadiq, Msmar Amir H, Abbasi Badaruddin, Alsulaiman Abdulla A, Alabdali Majed
Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia.
Department of Research Statistical Support, Deanship of Scientific Research, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia.
J Neurosci Rural Pract. 2019 Jan-Mar;10(1):106-112. doi: 10.4103/jnrp.jnrp_136_18.
Medication nonadherence is a significant barrier in achieving seizure freedom in patients with epilepsy. There is a deficiency of data about the reasons for nonadherence in Saudi population.
The aim of this study is to prove the existence of nonadherence to antiepileptic drugs (AEDs) in patients with epilepsy and identify the responsible factors.
This is a prospective, cross-sectional study carried in the Department of Neurology at King Fahd Hospital of the University affiliated with Imam Abdulrahman Bin Faisal University.
Patients of all ages diagnosed to have epilepsy as mentioned in their medical record and taking antiepileptic medications were interviewed using a questionnaire.
Statistical analysis was performed using IBM Statistical Package for the Social Sciences version 21 (IBM Corp., Armonk, NY, USA). Statistical significance was defined as two-tailed with a ≤ 0.05.
Among 152 participants, 52.6% were male and 47.4% were female. Mean age of the patients was 28 ± 14.3 (mean ± standard deviation) years. Of 152 patients, 48.7% were found to be nonadherent to their AED therapy. The most commonly identified factor was forgetfulness. Nonadherence was significantly associated with poor seizure control ( = 0.002).
Nonadherence to the AED is common among patients with epilepsy and affects seizure control adversely.
药物治疗依从性不佳是癫痫患者实现无癫痫发作的一个重大障碍。沙特人群中关于不依从原因的数据匮乏。
本研究的目的是证实癫痫患者存在抗癫痫药物（AEDs）治疗不依从情况，并确定相关因素。
这是一项在伊玛目阿卜杜勒拉赫曼·本·费萨尔大学附属法赫德国王医院神经科进行的前瞻性横断面研究。
使用问卷对病历中诊断为癫痫且正在服用抗癫痫药物的各年龄段患者进行访谈。
使用IBM社会科学统计软件包第21版（IBM公司，美国纽约州阿蒙克）进行统计分析。统计学显著性定义为双侧检验，P≤0.05。
152名参与者中，52.6%为男性，47.4%为女性。患者的平均年龄为28±14.3（均值±标准差）岁。152名患者中，48.7%被发现抗癫痫药物治疗不依从。最常见的因素是遗忘。不依从与癫痫控制不佳显著相关（P = 0.002）。
抗癫痫药物治疗不依从在癫痫患者中很常见，并对癫痫控制产生不利影响。
