Zhang Yuqian, Sheng Zixuan, Xiao Jing, Li Yang, Huang Jie, Jia Jinjing, Zeng Xiansi, Li Li
Research Center of Neuroscience, Jiaxing University Medical College, Jiaxing, China.
Department of Physiology, Jiaxing University Medical College, Jiaxing, China.
Front Pharmacol. 2023 Aug 15;14:1265172. doi: 10.3389/fphar.2023.1265172. eCollection 2023.
Since the first 70 years of reporting cancer chemotherapy, malignant tumors have been the second most common cause of death in children and adults. Currently, the commonly used anti-cancer methods include surgery, chemotherapy, radiotherapy, and immunotherapy. Although these treatment methods could alleviate cancer, they lead to different forms of side effects and have no particularly significant effect on prolonging the patients' life span. Glycyrrhizic acid (GL), a native Chinese herbal extract, has a wide range of pharmacological effects, such as anti-cancer, anti-inflammatory, antioxidant, and immune regulation. In this review, the anti-cancer effects and mechanisms of GL are summarized in various cancers. The inhibition of GL on chemotherapy-induced side effects, including hepatotoxicity, nephrotoxicity, genotoxicity, neurotoxicity and pulmonary toxicity, is highlighted. Therefore, GL may be a promising and ideal drug for cancer therapy.
自报道癌症化疗的最初70年以来，恶性肿瘤一直是儿童和成人中第二大常见死因。目前，常用的抗癌方法包括手术、化疗、放疗和免疫疗法。尽管这些治疗方法可以缓解癌症，但它们会导致不同形式的副作用，并且对延长患者的寿命没有特别显著的效果。甘草酸（GL）是一种天然的中草药提取物，具有广泛的药理作用，如抗癌、抗炎、抗氧化和免疫调节。在这篇综述中，总结了GL在各种癌症中的抗癌作用和机制。重点介绍了GL对化疗引起的副作用的抑制作用，包括肝毒性、肾毒性、遗传毒性、神经毒性和肺毒性。因此，GL可能是一种有前景的理想癌症治疗药物。
