Hernandez-Unzueta Iera, Telleria-Gonzalez Uxue, Aransay Ana María, Martin Rodriguez José Ezequiel, Sanz Eduardo, Márquez Joana
Cell Biology and Histology Department, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, Spain.
Genome Analysis Platform, CIC Biogune, Derio, Spain.
Front Pharmacol. 2025 Mar 19;16:1540217. doi: 10.3389/fphar.2025.1540217. eCollection 2025.
Cancer is one of the leading causes of death worldwide. Many therapies are being used to treat this disease, however, new treatments are now being implemented, since they are not always effective and their secondary effects represent one of the main reasons for cancer patients' loss of life quality during the progression of the disease. In this scenario, Ocoxin is a mixture of plant extracts, amino acids, vitamins and minerals, known for its antioxidant, anti-inflammatory and immunoregulatory properties, which has shown to exert antitumor effects in many cancers. The aim of this study is to elucidate the mechanism of action of the compound in colorectal cancer, triple negative breast cancer, pancreatic cancer and prostate cancer. Analyses performed through RNA sequencing revealed that the main effect of Ocoxin appears to be the alteration of cell metabolism, especially inducing the process of ferroptosis. Nevertheless, the modulation of the cell cycle was also remarkable. Ocoxin altered 13 genes in common in all the four cancers that were not only associated to metabolism and cell cycle but were also involved in the integrated stress response and unfolded protein response, suggesting that the compound causes the induction of cell death through several pathways. Although the mechanisms vary according to the type of cancer, this study highlights the potential of Ocoxin as an adjunctive treatment to improve outcomes in cancer therapy.
癌症是全球主要死因之一。目前有多种疗法用于治疗这种疾病，然而，由于现有疗法并非总是有效，且其副作用是癌症患者在疾病进展过程中生活质量下降的主要原因之一，因此现在正在采用新的治疗方法。在这种情况下，奥克辛是一种植物提取物、氨基酸、维生素和矿物质的混合物，以其抗氧化、抗炎和免疫调节特性而闻名，已显示在多种癌症中发挥抗肿瘤作用。本研究的目的是阐明该化合物在结直肠癌、三阴性乳腺癌、胰腺癌和前列腺癌中的作用机制。通过RNA测序进行的分析表明，奥克辛的主要作用似乎是改变细胞代谢，尤其是诱导铁死亡过程。然而，对细胞周期的调节也很显著。奥克辛在所有四种癌症中共同改变了13个基因，这些基因不仅与代谢和细胞周期相关，还参与综合应激反应和未折叠蛋白反应，这表明该化合物通过多种途径诱导细胞死亡。尽管具体机制因癌症类型而异，但本研究突出了奥克辛作为辅助治疗以改善癌症治疗效果的潜力。
