Riaz Adeel, Abbas Taskheer, Raza Syed Mohsin, Hurrairah Abu, Jamshed Arif
General Surgery, The Brooklyn Hospital Center, Brooklyn, USA.
Radiation Oncology, Rutgers Robert Wood Johnson Medical School, New Brunswick, USA.
Cureus. 2023 Jul 29;15(7):e42669. doi: 10.7759/cureus.42669. eCollection 2023 Jul.
Epithelial-myoepithelial carcinoma (EMC) is a rare clinical entity that affects glandular tissues, most commonly salivary glands. EMC of parapharyngeal space is exceedingly rare. Surgery is the mainstay of treatment with or without chemotherapy, radiotherapy, or both. Due to the rarity of the disease, select cases where surgery is not possible present a management conundrum. We present a case of locally advanced, stage IVa EMC of parapharyngeal space that was treated with upfront definitive radiotherapy. Radiotherapy treatment alone led to long-term disease control in both clinical and radiological follow-ups. The patient was followed for more than eight years posttreatment with no disease recurrence, enjoying the normal activities of life with no late toxicities including xerostomia. This case report highlights the role of radiotherapy in the management of such patients, and more studies are required in this context for surgical candidates with positive disease margins.
上皮-肌上皮癌（EMC）是一种罕见的临床疾病，主要累及腺组织，最常见于唾液腺。咽旁间隙的EMC极为罕见。手术是主要的治疗方法，可联合或不联合化疗、放疗或两者。由于该疾病罕见，对于无法进行手术的特定病例，治疗面临难题。我们报告一例局部晚期、IVa期咽旁间隙EMC患者，接受了 upfront 根治性放疗。单纯放疗在临床和影像学随访中均实现了长期疾病控制。患者治疗后随访超过八年，无疾病复发，能正常生活，无口干等晚期毒性反应。本病例报告强调了放疗在此类患者管理中的作用，对于手术切缘阳性的手术候选患者，在此背景下还需要更多研究。
