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病例报告:探索替度鲁肽作为难治性显微镜下结肠炎的一种治疗选择:见解与启示。

Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications.

作者信息

Rim Daniel Sungku, Shin Jeong-Hun, Jacoba Isa, Sharma Kavita, Kim Dong Wook

机构信息

Department of Medicine, Section of Endocrinology, Diabetes, Nutrition and Weight Management, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, United States.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.

出版信息

Front Med (Lausanne). 2023 Aug 15;10:1231565. doi: 10.3389/fmed.2023.1231565. eCollection 2023.

Abstract

Microscopic colitis is a chronic inflammatory condition of the colon characterized by chronic watery diarrhea, generally with endoscopically normal or nonspecific findings, and can be diagnosed by histopathological examination of colon mucosal biopsies. Some patients experience severe symptoms that do not respond to conventional medical treatment. A glucagon-like peptide-2 (GLP-2) analog, teduglutide, is used in patients with short bowel syndrome (SBS) dependent on parenteral support. In this case report, we describe a patient with microscopic colitis who demonstrated significant symptom improvement following teduglutide treatment.

摘要

显微镜下结肠炎是一种结肠的慢性炎症性疾病,其特征为慢性水样腹泻,内镜检查通常正常或无特异性表现,可通过结肠黏膜活检的组织病理学检查进行诊断。一些患者会出现严重症状,对传统药物治疗无反应。一种胰高血糖素样肽-2(GLP-2)类似物替度鲁肽,用于依赖肠外支持的短肠综合征(SBS)患者。在本病例报告中,我们描述了一名显微镜下结肠炎患者,其在接受替度鲁肽治疗后症状有显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420e/10462905/9843f161dcd1/fmed-10-1231565-g001.jpg

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