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病例报告：探索替度鲁肽作为难治性显微镜下结肠炎的一种治疗选择：见解与启示。

Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications.

作者信息

Rim Daniel Sungku, Shin Jeong-Hun, Jacoba Isa, Sharma Kavita, Kim Dong Wook

机构信息

Department of Medicine, Section of Endocrinology, Diabetes, Nutrition and Weight Management, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, United States.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.

出版信息

Front Med (Lausanne). 2023 Aug 15;10:1231565. doi: 10.3389/fmed.2023.1231565. eCollection 2023.

DOI:10.3389/fmed.2023.1231565
PMID:37649980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10462905/
Abstract

Microscopic colitis is a chronic inflammatory condition of the colon characterized by chronic watery diarrhea, generally with endoscopically normal or nonspecific findings, and can be diagnosed by histopathological examination of colon mucosal biopsies. Some patients experience severe symptoms that do not respond to conventional medical treatment. A glucagon-like peptide-2 (GLP-2) analog, teduglutide, is used in patients with short bowel syndrome (SBS) dependent on parenteral support. In this case report, we describe a patient with microscopic colitis who demonstrated significant symptom improvement following teduglutide treatment.

摘要

显微镜下结肠炎是一种结肠的慢性炎症性疾病，其特征为慢性水样腹泻，内镜检查通常正常或无特异性表现，可通过结肠黏膜活检的组织病理学检查进行诊断。一些患者会出现严重症状，对传统药物治疗无反应。一种胰高血糖素样肽-2（GLP-2）类似物替度鲁肽，用于依赖肠外支持的短肠综合征（SBS）患者。在本病例报告中，我们描述了一名显微镜下结肠炎患者，其在接受替度鲁肽治疗后症状有显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420e/10462905/2bcefb042e9b/fmed-10-1231565-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420e/10462905/9843f161dcd1/fmed-10-1231565-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420e/10462905/2bcefb042e9b/fmed-10-1231565-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420e/10462905/9843f161dcd1/fmed-10-1231565-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420e/10462905/2bcefb042e9b/fmed-10-1231565-g002.jpg

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本文引用的文献

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Vedolizumab in Refractory Microscopic Colitis: An International Case Series.维得利珠单抗治疗难治性显微镜下结肠炎：一项国际病例系列研究。
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2
American Gastroenterological Association Institute Guideline on the Medical Management of Microscopic Colitis.美国胃肠病学会关于显微镜下结肠炎药物治疗的指南
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Microscopic colitis: clinical and pathologic perspectives.
显微镜结肠炎：临床与病理透视。
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Efficacy of anti-TNF therapies in refractory severe microscopic colitis.抗 TNF 治疗在难治性重度显微镜结肠炎中的疗效。
J Crohns Colitis. 2011 Dec;5(6):612-8. doi: 10.1016/j.crohns.2011.05.001. Epub 2011 Jun 8.
6
Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome.随机安慰剂对照试验研究特杜格鲁肽减少短肠综合征患者肠外营养和/或静脉输液需求的作用。
Gut. 2011 Jul;60(7):902-14. doi: 10.1136/gut.2010.218271. Epub 2011 Feb 11.
7
Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2.肠神经通路介导胰高血糖素样肽2的抗炎作用。
Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G211-21. doi: 10.1152/ajpgi.00530.2006. Epub 2007 Mar 29.
8
Clinical significance of GLP-2 in short-bowel syndrome.胰高血糖素样肽-2在短肠综合征中的临床意义。
J Nutr. 2003 Nov;133(11):3721-4. doi: 10.1093/jn/133.11.3721.
9
Budesonide treatment for collagenous colitis: a randomized, double-blind, placebo-controlled, multicenter trial.布地奈德治疗胶原性结肠炎：一项随机、双盲、安慰剂对照、多中心试验。
Gastroenterology. 2002 Oct;123(4):978-84. doi: 10.1053/gast.2002.36042.
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Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine.
Gastroenterology. 2001 May;120(6):1483-4. doi: 10.1053/gast.2001.23976.