Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, 111 Mason Farm Road, Molecular Biology Research Building 5341C, Chapel Hill, NC 27599, USA.
Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, 111 Mason Farm Road, Molecular Biology Research Building 5341C, Chapel Hill, NC 27599, USA.
Mol Cell Endocrinol. 2024 Nov 1;593:112339. doi: 10.1016/j.mce.2024.112339. Epub 2024 Aug 5.
Enteroendocrine cells (EECs) are well-known for their systemic hormonal effects, especially in the regulation of appetite and glycemia. Much less is known about how the products made by EECs regulate their local environment within the intestine. Here, we focus on paracrine interactions between EECs and other intestinal cells as they regulate three essential aspects of intestinal homeostasis and physiology: 1) intestinal stem cell function and proliferation; 2) nutrient absorption; and 3) mucosal barrier function. We also discuss the ability of EECs to express multiple hormones, describe in vitro and in vivo models to study EECs, and consider how EECs are altered in GI disease.
肠内分泌细胞 (EECs) 以其全身性的激素作用而闻名，尤其是在调节食欲和血糖方面。然而，人们对 EECs 产生的产物如何调节肠道内局部环境知之甚少。在这里，我们重点关注 EECs 与其他肠道细胞之间的旁分泌相互作用，因为它们调节肠道内稳态和生理学的三个重要方面：1) 肠道干细胞功能和增殖；2) 营养吸收；3) 黏膜屏障功能。我们还讨论了 EECs 表达多种激素的能力，描述了用于研究 EECs 的体外和体内模型，并考虑了 EECs 在胃肠道疾病中的变化。
