Li Yuanli, He Xiaoyi, Deng Ling, Chen Hai, Chen Xi, Mao Xuhu, Xiang Yang
Department of Clinical Laboratory, Sanya People's Hospital, Sanya, Hainan, People's Republic of China.
Department of Clinical Microbiology and Immunology, College of Pharmacy and Laboratory Medicine Science, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Infect Drug Resist. 2023 Aug 25;16:5613-5625. doi: 10.2147/IDR.S421739. eCollection 2023.
, the causative agent of melioidosis can be responsible for a wide spectrum of clinical manifestations and heterogeneous prognoses, with a high mortality in the acute onset. We report a case of a deep abdominal abscess with sepsis secondary to melioidosis in a young farmer from a non-high-risk population. Emergency medical treatment was administered according to the detection of serum antibodies against Hcp1, the results of which provided etiological evidence of infection for the timely and properly antimicrobial therapy in the absence of direct evidence of melioidosis. To our knowledge, this is the first reported case of serodiagnosis of acute exacerbation of melioidosis in China.
类鼻疽病的病原体可导致广泛的临床表现和异质性预后,急性发作时死亡率很高。我们报告一例来自非高危人群的年轻农民因类鼻疽病继发深部腹部脓肿伴败血症的病例。根据针对Hcp1的血清抗体检测进行了紧急药物治疗,其结果为在缺乏类鼻疽病直接证据的情况下及时、正确地进行抗菌治疗提供了感染的病因学证据。据我们所知,这是中国首例报告的类鼻疽病急性加重的血清学诊断病例。