University of Minnesota, St. Paul, MN.
US Department of Agriculture, Ames, IA.
Vet Pathol. 2024 Mar;61(2):298-302. doi: 10.1177/03009858231196797. Epub 2023 Aug 31.
In September 2020, an outbreak of epizootic hemorrhagic disease occurred in captive reindeer () and was associated with neurological signs and mortality. Four reindeer died or were euthanized after acute illness over a 12-day period. Affected reindeer displayed abnormal behavior, neurologic signs, lethargy, and/or lameness. The most consistent gross finding was dark red streaks throughout the adrenal gland cortices (4/4). One animal had acute hemorrhage involving the subcutis and skeletal muscles over the ventrolateral body wall and back, and abomasal serosa. Histologically, the most common lesions were adrenal gland cortical hemorrhage (4/4) with necrosis (3/4) and lymphoplasmacytic meningoencephalitis with gliosis, glial nodules, satellitosis, and nonsuppurative perivascular cuffing (4/4). The brain lesions were most frequent in the gray matter of the cerebrum, hippocampus, and thalamus but also involved the cerebellum and brainstem. Epizootic hemorrhagic disease virus serotype 6 was detected through PCR and sequencing of the spleen in all cases.
2020 年 9 月，圈养驯鹿中爆发了流行性出血性疾病（），伴有神经症状和死亡率。在 12 天的时间内，4 只驯鹿在急性疾病后死亡或被安乐死。患病驯鹿表现出异常行为、神经症状、嗜睡和/或跛行。最一致的大体发现是整个肾上腺皮质有暗红色条纹（4/4）。一只动物有急性出血，涉及腹外侧体壁和背部的皮下组织和骨骼肌，以及皱胃浆膜。组织病理学上，最常见的病变是肾上腺皮质出血（4/4）伴坏死（3/4），以及淋巴浆细胞性脑膜脑炎伴神经胶质增生、神经胶质结节、卫星现象和非化脓性血管周围袖套（4/4）。大脑病变最常见于大脑、海马体和丘脑的灰质，但也涉及小脑和脑干。通过对所有病例脾脏的 PCR 和测序，检测到了 6 型流行性出血性疾病病毒。
