脑膜瘤的分子遗传学特征。
Molecular genetic features of meningiomas.
机构信息
Burdenko Neurosurgical Center, Moscow, Russia.
Loginov Moscow Clinical Scientific Practical Center, Moscow, Russia.
出版信息
Zh Vopr Neirokhir Im N N Burdenko. 2023;87(4):101-106. doi: 10.17116/neiro202387041101.
Meningioma is the most common primary tumor of the central nervous system. Traditional classification is based on histological properties of tumors and distinguishes different grades of meningioma malignancy. However, knowledge about different molecular mechanisms of tumor provided new data on genetic features of meningiomas. The authors analyze current available data on the main driver mutations, new classifications based on molecular genetic characteristics and potential targets for therapy.
脑膜瘤是中枢神经系统最常见的原发性肿瘤。传统分类基于肿瘤的组织学特性，并区分不同级别脑膜瘤的恶性程度。然而，关于肿瘤不同分子机制的知识提供了脑膜瘤遗传特征的新数据。作者分析了主要驱动突变的现有数据、基于分子遗传学特征的新分类以及治疗的潜在靶点。
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