Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
China International Neuroscience Institute (China-INI), Beijing, China.
Eur J Neurol. 2024 Nov;31(11):e16047. doi: 10.1111/ene.16047. Epub 2023 Aug 31.
Ischemic stroke is a significant cause of disability and death worldwide. Randomized clinical trials (RCTs) are important in changing guidelines and treatment strategies. This study aimed to analyze the progress of RCTs in ischemic stroke and to guide future research directions.
Ischemic stroke-related RCT articles were identified in six high-impact medical journals using the Web of Science Core Collection database. Google Scholar was used to check whether relevant articles were included in the guidelines. The characteristics of these articles were analyzed and future research hotspots were predicted.
389 relevant articles were included in the analysis. The number of articles increased rapidly from 1972 to 2022, from 5 (1.3%; 1972-1982) to 208 (53.5%; 2013-2022) articles. 338 (86.9%) articles were included in relevant guidelines. According to corresponding author location, Europe was the source of the highest number of publications (183; 47.0%), followed by the Americas (152; 39.1%) and the Western Pacific (54; 13.9%). The number of publications steadily increased over time in the USA, England, Canada, Australia, Germany, and France, and surged in China and Spain, especially in the last 5 years. In recent years, endovascular therapy has accounted for the majority of ischemic stroke-related RCT articles.
Numerous RCTs related to ischemic stroke have been conducted in recent decades, and both the number of articles and their contribution to guideline updates are increasing. Also, a shift in research topics was observed. However, great regional imbalances in this research exist, calling for more research to be conducted in specific regions to promote the generalizability of trial conclusions.
缺血性脑卒中是全球范围内导致残疾和死亡的重要原因。随机临床试验（RCT）对于改变指南和治疗策略非常重要。本研究旨在分析缺血性脑卒中 RCT 的进展，并指导未来的研究方向。
使用 Web of Science 核心合集数据库，在 6 种高影响力医学期刊中检索与缺血性脑卒中相关的 RCT 文章。使用 Google Scholar 检查相关文章是否被纳入指南。分析这些文章的特征，并预测未来的研究热点。
共纳入 389 篇相关文章。文章数量从 1972 年至 2022 年快速增长，从 5 篇（1.3%；1972-1982 年）增加到 208 篇（53.5%；2013-2022 年）。338 篇（86.9%）文章被纳入相关指南。根据通讯作者所在地，欧洲发表的文章数量最多（183 篇；47.0%），其次是美洲（152 篇；39.1%）和西太平洋（54 篇；13.9%）。美国、英国、加拿大、澳大利亚、德国和法国的发文数量随时间稳步增长，而中国和西班牙的发文数量在近几年迅速增加，尤其是在过去 5 年。近年来，血管内治疗在缺血性脑卒中相关 RCT 中占多数。
近几十年来，开展了大量与缺血性脑卒中相关的 RCT，文章数量及其对指南更新的贡献都在增加。同时，研究主题也发生了转变。然而，这种研究存在明显的地区不平衡，需要在特定地区开展更多研究，以促进试验结论的推广。
