Liu Guangjie, Li Tianhua, Yang Anming, Zhang Xin, Qi Songtao, Feng Wenfeng
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Front Aging Neurosci. 2023 Jan 5;14:1057214. doi: 10.3389/fnagi.2022.1057214. eCollection 2022.
Microglia have been identified for a century. In this period, their ontogeny and functions have come to light thanks to the tireless efforts of scientists. However, numerous documents are being produced, making it challenging for scholars, especially those new to the field, to understand them thoroughly. Therefore, having a reliable method for quickly grasping a field is crucial.
We searched and downloaded articles from the Web of Science Core Collection with "microglia" or "microglial" in the title from 2002 to 2021. Eventually, 12,813 articles were located and, using CiteSpace and VOSviewer, the fundamental data, knowledge domains, hot spots, and emerging trends, as well as the influential literature in the field of microglia research, were analyzed.
Following 2011, microglia publications grew significantly. The two prominent journals are Glia and J Neuroinflamm. The United States and Germany dominated the microglia study. The primary research institutions are Harvard Univ and Univ Freiburg, and the leading authors are Prinz Marco and Kettenmann Helmut. The knowledge domains of microglia include eight directions, namely neuroinflammation, lipopolysaccharide, aging, neuropathic pain, macrophages, Alzheimer's disease, retina, and apoptosis. Microglial phenotype is the focus of research; while RNA-seq, exosome, and glycolysis are emerging topics, a microglial-specific marker is still a hard stone. We also identified 19 influential articles that contributed to the study of microglial origin (Mildner A 2007; Ginhoux F 2010), identity (Butovsky O 2014), homeostasis (Cardona AE 2006; Elmore MRP 2014); microglial function such as surveillance (Nimmerjahn A 2005), movement (Davalos D 2005; Haynes SE 2006), phagocytosis (Simard AR 2006), and synapse pruning (Wake H 2009; Paolicelli RC 2011; Schafer DP 2012; Parkhurst CN 2013); and microglial state/phenotype associated with disease (Keren-Shaul H 2017), as well as 5 review articles represented by Kettenmann H 2011.
Using bibliometrics, we have investigated the fundamental data, knowledge structure, and dynamic evolution of microglia research over the previous 20 years. We hope this study can provide some inspiration and a reference for researchers studying microglia in neuroscience.
小胶质细胞已被发现一个世纪了。在此期间，得益于科学家们的不懈努力，它们的个体发育和功能已逐渐明晰。然而，相关文献数量众多，这使得学者们，尤其是该领域的新手，难以全面理解这些文献。因此，拥有一种可靠的方法来快速掌握一个领域至关重要。
我们在科学网核心合集中搜索并下载了2002年至2021年标题中包含“小胶质细胞”或“小胶质的”的文章。最终，共找到12813篇文章，并使用CiteSpace和VOSviewer对小胶质细胞研究领域的基础数据、知识领域、热点、新兴趋势以及有影响力的文献进行了分析。
2011年之后，关于小胶质细胞的出版物数量显著增长。两个突出的期刊是《胶质细胞》和《神经炎症杂志》。美国和德国在小胶质细胞研究方面占据主导地位。主要研究机构是哈佛大学和弗莱堡大学，主要作者是马尔科·普林茨和赫尔穆特·凯特曼。小胶质细胞的知识领域包括八个方向，即神经炎症、脂多糖、衰老、神经性疼痛、巨噬细胞、阿尔茨海默病、视网膜和细胞凋亡。小胶质细胞表型是研究的重点；虽然RNA测序（RNA-seq）、外泌体和糖酵解是新兴主题，但小胶质细胞特异性标志物仍是一个难题。我们还确定了19篇有影响力的文章，这些文章对小胶质细胞起源（米尔德纳A，2007年；金胡克斯F，2010年）、身份（布托夫斯基O，2014年）、内环境稳态（卡尔多纳AE，2006年；埃尔莫尔MRP，2014年）的研究有贡献；小胶质细胞功能，如监测（尼默亚恩A，2005年）、移动（达瓦洛斯D，2005年；海恩斯SE，2006年）、吞噬作用（西马尔德AR，2006年）和突触修剪（韦克H，2009年；保利塞利RC，2011年；谢弗DP，2012年；帕克赫斯特CN，2013年）；以及与疾病相关的小胶质细胞状态/表型（凯伦-绍尔H，2017年），还有以凯特曼H 2011年为代表的5篇综述文章。
我们使用文献计量学方法研究了过去20年中小胶质细胞研究的基础数据、知识结构和动态演变。我们希望这项研究能为神经科学领域研究小胶质细胞的研究人员提供一些启发和参考。
