Department of Biology, University of Fribourg , Fribourg, Switzerland.
Swiss Institute of Bioinformatics , Lausanne, Switzerland.
mBio. 2023 Oct 31;14(5):e0085723. doi: 10.1128/mbio.00857-23. Epub 2023 Aug 31.
Bacteria communicate by exchanging chemical signals, some of which are volatile and can remotely reach other organisms. HCN was one of the first volatiles discovered to severely impact exposed organisms by inhibiting their respiration. Using HCN-deficient mutants in two strains, we demonstrate that HCN's impact goes beyond the sole inhibition of respiration and affects both emitting and receiving bacteria in a global way, modulating their motility, biofilm formation, and production of antimicrobial compounds. Our data suggest that bacteria could use HCN not only to control their own cellular functions, but also to remotely influence the behavior of other bacteria sharing the same environment. Since HCN emission occurs in both clinically and environmentally relevant , these findings are important to better understand or even modulate the expression of bacterial traits involved in both virulence of opportunistic pathogens and in biocontrol efficacy of plant-beneficial strains.
细菌通过交换化学信号进行通讯，其中一些信号是挥发性的，可以远程到达其他生物体。HCN 是最早发现的挥发性物质之一，它通过抑制呼吸作用，严重影响暴露的生物体。在两个菌株中使用缺乏 HCN 的突变体，我们证明 HCN 的影响不仅限于对呼吸作用的单一抑制，而且以全局方式影响发出和接收细菌，调节它们的运动性、生物膜形成和抗菌化合物的产生。我们的数据表明，细菌不仅可以使用 HCN 来控制自己的细胞功能，还可以远程影响共享同一环境的其他细菌的行为。由于 HCN 的排放既存在于临床相关环境中，也存在于环境相关环境中，因此这些发现对于更好地理解甚至调节与机会性病原体毒力和植物有益菌株生物防治效果相关的细菌特性的表达都很重要。
