Department of Emergency, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Yangpu District, Shanghai, 200433, China.
Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Yangpu District, Shanghai, 200433, China.
Appl Biochem Biotechnol. 2024 Jun;196(6):3344-3355. doi: 10.1007/s12010-023-04686-5. Epub 2023 Aug 31.
Pachymic acid (PA), a natural extract from Poria cocos (Schw.) Wolf, possesses anti-inflammatory and anti-oxidative properties. However, it is still unknown whether PA can protect against bleomycin (BLM)-induced pulmonary fibrosis (PF). In this study, we investigated the effects of PA in mice administered BLM. Our results showed that PA significantly improved lung damage and pathological manifestations. Additionally, PA reduced the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α, while increasing the level of IL-10. PA also decreased the levels of hydroxyproline and malondialdehyde, and increased the activities of superoxide dismutase and glutathione peroxidase in lung tissue. Furthermore, PA inhibited the increases in pyrin domain-containing protein 3 (NLRP3), ASC, IL-1β, P20, and TXNIP induced by BLM. In conclusion, our study demonstrated the protective effects of PA against BLM-induced PF in mice by suppressing fibrotic, inflammatory, and oxidative stress pathways.
茯苓酸（PA）是从茯苓（Schw.）Wolf 中提取的一种天然产物，具有抗炎和抗氧化作用。然而，目前尚不清楚 PA 是否可以预防博莱霉素（BLM）诱导的肺纤维化（PF）。在本研究中，我们研究了 PA 对 BLM 处理小鼠的影响。结果表明，PA 可显著改善肺损伤和病理表现。此外，PA 降低了白细胞介素（IL）-6 和肿瘤坏死因子（TNF）-α的水平，同时增加了 IL-10 的水平。PA 还降低了羟脯氨酸和丙二醛的水平，并增加了肺组织中超氧化物歧化酶和谷胱甘肽过氧化物酶的活性。此外，PA 抑制了博莱霉素诱导的吡嗪结构域包含蛋白 3（NLRP3）、ASC、IL-1β、P20 和 TXNIP 的增加。综上所述，我们的研究表明 PA 通过抑制纤维化、炎症和氧化应激通路，对 BLM 诱导的 PF 具有保护作用。
