Department of Materials Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou 511436, China.
Laboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
ACS Appl Mater Interfaces. 2023 Sep 13;15(36):42182-42195. doi: 10.1021/acsami.3c05728. Epub 2023 Aug 31.
Microwave thermal dynamic therapy (MTDT), which combines thermal effects and reactive oxygen species (ROS) by microwave activation, seems to be a promising anticancer therapeutic method. A multifunctional agent for achieving synergistic localized cancer treatment is the key to exploit the strategy to inhibit tumor cell recurrence and metastasis. In the study, a ZIF-67 based theranostic agent loaded with metal-chalcogenide open framework 3 (MCOF3) and heat shock protein 70 (HSP70) as the inner component was studied, coupled with targeting cancer cell membrane (TCM) as the biomimetic outer shell. We found that metal ions in MCOF3 enabled the composite agents to show peroxide-like activity to produce OH and destroy cancer cells. And then, the microwave (MW) thermal sensitizer of ZIF-67 was used to specifically convert the MW energy into thermal energy and selectively heat the tumor via the cell's targeting. Additionally, the effect of continuous MW thermal therapy has been shown to promote the expression of HSP70, and further activate the effector of CD4 T cell and CD8α T cell. As such, the agents effectively inhibit the tumor cell growth under MW irradiation and due to the synergistic effects of MTDT and immune cell activation. The study provides an emerging strategy to ablation cancer effectively.
微波热动力学疗法（MTDT）通过微波激活结合热效应和活性氧物质（ROS），似乎是一种很有前途的抗癌治疗方法。多功能试剂可实现协同局部癌症治疗，是利用该策略抑制肿瘤细胞复发和转移的关键。在本研究中，研究了一种基于沸石咪唑酯骨架-67（ZIF-67）的治疗剂，其负载金属-硫属化物开放式框架 3（MCOF3）和热休克蛋白 70（HSP70）作为内部成分，并与靶向癌细胞膜（TCM）作为仿生外壳相结合。我们发现，MCOF3 中的金属离子使复合试剂能够表现出过氧化物样活性，产生 OH 并破坏癌细胞。然后，ZIF-67 的微波（MW）热敏剂被用于将 MW 能量专门转化为热能，并通过细胞靶向选择性加热肿瘤。此外，连续 MW 热疗的效果已被证明可以促进 HSP70 的表达，并进一步激活 CD4 T 细胞和 CD8α T 细胞的效应器。因此，这些试剂在 MW 辐射下有效地抑制了肿瘤细胞的生长，并由于 MTDT 和免疫细胞激活的协同作用。该研究为有效消融癌症提供了一种新的策略。
