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On the fidelity of DNA replication. Effect of divalent metal ion activators and deoxyrionucleoside triphosphate pools on in vitro mutagenesis.

作者信息

Kunkel T A, Loeb L A

出版信息

J Biol Chem. 1979 Jul 10;254(13):5718-25.

PMID:376517
Abstract
摘要

相似文献

1
On the fidelity of DNA replication. Effect of divalent metal ion activators and deoxyrionucleoside triphosphate pools on in vitro mutagenesis.关于DNA复制的保真度。二价金属离子激活剂和脱氧核糖核苷三磷酸库对体外诱变的影响。
J Biol Chem. 1979 Jul 10;254(13):5718-25.
2
On the fidelity of DNA replication. Metal activation of Escherichia coli DNA polymerase I.关于DNA复制的保真度。大肠杆菌DNA聚合酶I的金属激活
J Biol Chem. 1979 Jan 10;254(1):107-11.
3
On the fidelity of DNA replication. Accuracy of Escherichia coli DNA polymerase I.论DNA复制的保真度。大肠杆菌DNA聚合酶I的准确性。
J Biol Chem. 1979 Jan 10;254(1):101-6.
4
Mutagenesis during in vitro DNA synthesis.体外DNA合成过程中的诱变作用。
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1924-8. doi: 10.1073/pnas.75.4.1924.
5
Replication of bacteriophage M13. X. M13 replication in a mutant of Escherichia coli defective in the 5' leads to 3' exonuclease associated with DNA polymerase I.噬菌体M13的复制。X. M13在大肠杆菌5'至3'核酸外切酶（与DNA聚合酶I相关）缺陷型突变体中的复制。
J Mol Biol. 1976 Sep 25;106(3):589-604. doi: 10.1016/0022-2836(76)90253-9.
6
Effect of manganese ions on the incorporation of dideoxynucleotides by bacteriophage T7 DNA polymerase and Escherichia coli DNA polymerase I.锰离子对噬菌体T7 DNA聚合酶和大肠杆菌DNA聚合酶I掺入双脱氧核苷酸的影响。
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4076-80. doi: 10.1073/pnas.86.11.4076.
7
Effect of metal cations on misincorporation by E. coli DNA polymerases.金属阳离子对大肠杆菌DNA聚合酶错配掺入的影响。
Biochem Biophys Res Commun. 1977 Aug 8;77(3):854-60. doi: 10.1016/s0006-291x(77)80056-9.
8
Specificity of the catalytic interaction of human DNA polymerase beta with nucleic acid substrates.人DNA聚合酶β与核酸底物催化相互作用的特异性
Biochemistry. 1982 Mar 30;21(7):1597-608. doi: 10.1021/bi00536a021.
9
Mutagenesis by alkylating agents: coding properties for DNA polymerase of poly (dC) template containing 3-methylcytosine.烷基化剂诱变：含3-甲基胞嘧啶的聚（dC）模板对DNA聚合酶的编码特性
Biochimie. 1982 Aug-Sep;64(8-9):637-41. doi: 10.1016/s0300-9084(82)80103-x.
10
Mechanism of ultraviolet-induced mutagenesis: extent and fidelity of in vitro DNA synthesis on irradiated templates.紫外线诱导突变的机制：照射模板上体外DNA合成的程度和保真度。
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3037-41. doi: 10.1073/pnas.75.7.3037.

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For the Better or for the Worse? The Effect of Manganese on the Activity of Eukaryotic DNA Polymerases.是好是坏？锰对真核 DNA 聚合酶活性的影响。
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The catalytic mechanism, metal dependence, substrate specificity, and biodiversity of ribonuclease H.核糖核酸酶H的催化机制、金属依赖性、底物特异性及生物多样性。
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Human Mitochondrial DNA Polymerase Metal Dependent UV Lesion Bypassing Ability.
人类线粒体DNA聚合酶的金属依赖性紫外线损伤绕过能力。
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Events associated with DNA replication disruption are not observed in hydrogen peroxide-treated Escherichia coli.在过氧化氢处理的大肠杆菌中未观察到与 DNA 复制中断相关的事件。
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Manganese Is Required for the Rapid Recovery of DNA Synthesis following Oxidative Challenge in .锰对于. 氧化应激后 DNA 合成的快速恢复是必需的。
J Bacteriol. 2019 Nov 20;201(24). doi: 10.1128/JB.00426-19. Print 2019 Dec 15.
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Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/primer or by perturbing the polymerase reaction.二价离子通过改变模板/引物的结构或干扰聚合酶反应来减弱人DNA聚合酶α的DNA合成。
DNA Repair (Amst). 2016 Jul;43:24-33. doi: 10.1016/j.dnarep.2016.05.017. Epub 2016 May 12.
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Alternative divalent cations (Zn²⁺, Co²⁺, and Mn²⁺) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity.在对HIV-1逆转录酶活性而言最优的条件下，替代二价阳离子（锌离子、钴离子和锰离子）不具有致突变性。
BMC Biochem. 2015 May 3;16:12. doi: 10.1186/s12858-015-0041-x.
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Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine.人类 PrimPol DNA 聚合酶活性的动力学分析表明，该酶通常是一种易错酶，但能够准确地绕过 7,8-二氢-8-氧代-2'-脱氧鸟苷。
Biochemistry. 2014 Oct 21;53(41):6584-94. doi: 10.1021/bi501024u. Epub 2014 Oct 10.
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Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase β.金属依赖性构象激活解释了人类DNA聚合酶β跨O6-甲基鸟嘌呤的高度致突变性复制。
J Am Chem Soc. 2014 Apr 16;136(15):5709-21. doi: 10.1021/ja500172d. Epub 2014 Apr 2.
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Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.在 DNA 聚合酶活性部位中氨基芴-脱氧鸟嘌呤加合物的构象分析。
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