Qiu Weida, Cai Anping, Li Liwen, Feng Yingqing
Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, 510080, China.
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
ESC Heart Fail. 2023 Oct;10(5):2797-2806. doi: 10.1002/ehf2.14501. Epub 2023 Aug 31.
Gender differences in heart failure (HF), ranging from epidemiological and pathophysiological factors to therapeutic response and prognosis, have been well documented in Western countries, especially in Europe and North America. The above gender differences in HF found in Westerners are rarely investigated in Asians. In this review, we explore the worrying knowledge gap on the gender differences in HF that existed in Asia in contrast with Western populations based on the following four aspects: epidemiology, risk factors, therapy, and prognosis. Finally, we conclude that investigations of gender differences in HF in Asia lag behind those in Europe and North America. Future work is required to establish and better use the high-level, population-based cohorts and develop our own high-quality, convincing clinical trials to deliver robust gender-specific conclusions in Asia.
心力衰竭（HF）中的性别差异，从流行病学和病理生理因素到治疗反应及预后，在西方国家，尤其是欧洲和北美已有充分记录。西方人中上述心力衰竭的性别差异在亚洲人中很少被研究。在本综述中，我们基于以下四个方面探讨亚洲与西方人群相比在心力衰竭性别差异方面令人担忧的知识差距：流行病学、危险因素、治疗和预后。最后，我们得出结论，亚洲在心力衰竭性别差异方面的研究落后于欧洲和北美。未来需要开展工作，建立并更好地利用高水平、基于人群的队列研究，并开展我们自己高质量、有说服力的临床试验，以便在亚洲得出有力的性别特异性结论。
