National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez. Neuropathology Department, Av. Insurgentes Sur 3877, La Fama, Tlalpan, 14269, México City, Mexico.
Biological-Chemistry Area. Technological Institute of Veracruz. Calzada Miguel Angel de Quevedo 2779, 91860, Veracruz, Ver., Mexico.
Toxicon. 2023 Sep;233:107272. doi: 10.1016/j.toxicon.2023.107272. Epub 2023 Aug 29.
Anthurium schlechtendalii Kunth is used by the Zoque group in southeastern Mexico for kidney and urinary diseases, but its safety and effectiveness are unproven, therefore a model of adenine-induced renal failure in rats was performed. The rats were fed with solid and aqueous plant extracts for 4 weeks to study its effects on kidney histological morphology. Kidneys were examined, and statistical analysis was performed. The adenine-containing diet caused renal failure, characterized by crystal deposits, cystic dilatation of tubules, and micro-abscesses. Both extracts caused tubular damage and collagen increase without inflammation. However, when combined with adenine, the extracts showed some protective effects, although cystic dilatation and granulomatous inflammation were observed. The extracts at the tested doses resulted in glomerular and tubular damage, aggravating cystic degeneration, therefore, its indiscriminate use in Humans is not safe. Additionally, the extracts can serve as a model for studying renal damage without crystal deposits.
墨西哥东南部的佐克族人用臭菘治疗肾脏和泌尿系统疾病，但这种植物的安全性和有效性尚未得到证实，因此我们建立了腺嘌呤诱导的大鼠肾衰竭模型。大鼠连续 4 周经口给予植物的固体和水提物，以研究其对肾脏组织形态的影响。检查肾脏并进行统计学分析。腺嘌呤饮食导致肾衰竭，表现为晶体沉积、小管囊性扩张和微脓肿。两种提取物均引起管状损伤和胶原增加而无炎症。然而，当与腺嘌呤联合使用时，提取物显示出一些保护作用，尽管观察到囊性扩张和肉芽肿性炎症。在测试剂量下，提取物导致肾小球和肾小管损伤，加重囊性变性，因此，其在人类中的盲目使用是不安全的。此外，提取物可作为研究无晶体沉积的肾脏损伤模型。
