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产前维生素的有毒元素污染。

Toxic element contaminations of prenatal vitamins.

机构信息

Division of Environmental Medicine, Department of Medicine, New York University School of Medicine, 341 East 25(th) Street, New York, NY 10010, United States of America.

Division of Environmental Medicine, Department of Medicine, New York University School of Medicine, 341 East 25(th) Street, New York, NY 10010, United States of America.

出版信息

Toxicol Appl Pharmacol. 2023 Oct 15;477:116670. doi: 10.1016/j.taap.2023.116670. Epub 2023 Aug 29.


DOI:10.1016/j.taap.2023.116670
PMID:37652310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10874124/
Abstract

The detrimental effects of gestational and lactational exposure to adverse chemical agents are gathering increasing attention. In our study, the presence of toxic heavy metals in several prenatal vitamins from six brands available in supermarkets and pharmacies was measured using ICP mass spectrometry. Several toxic heavy metals were detected, some at levels that could have potential toxicity to the fetus and the mother as well. Previous studies have also detected toxic heavy metals in prenatal and other vitamins. One of the reasons for toxic heavy metals in "natural vitamins" sold to consumers is that they are produced from naturally grown material and not synthesized. They are likely exposed to the heavy metals from the ground that they are grown in and there has not been any significant attempt to get rid of them before the vitamin pill was sold to consumers. Thus, this problem is not an isolated issue and regulatory agencies should be dealing more aggressively than they have been doing. In fact, several papers have already been published showing similar findings as we are reporting here. The vitamin pills we analyzed have elevated levels of boron, aluminum, molybdenum, barium, lead, titanium, nickel, arsenic, strontium, and cadmium. The levels of total chromium were also elevated but we did not separately determine Cr(III) and the much more hazardous Cr(VI), because of the tedious procedure required to separate these two forms of Cr.

摘要

妊娠和哺乳期接触有害化学物质的不利影响越来越受到关注。在我们的研究中,使用 ICP 质谱法测量了超市和药店出售的六个品牌的几种产前维生素中的有毒重金属含量。检测到了几种有毒重金属,有些含量可能对胎儿和母亲都有潜在毒性。以前的研究也在产前维生素和其他维生素中检测到了有毒重金属。“天然维生素”中存在有毒重金属的原因之一是,它们是由天然生长的材料制成的,而不是合成的。它们可能会接触到生长的土壤中的重金属,而且在将维生素药丸出售给消费者之前,并没有采取任何有效措施来去除重金属。因此,这个问题并不是孤立的问题,监管机构应该采取比以往更积极的措施。事实上,已经有几篇论文发表,显示出与我们在这里报告的类似发现。我们分析的维生素丸中含有较高水平的硼、铝、钼、钡、铅、钛、镍、砷、锶和镉。总铬的含量也升高了,但由于需要繁琐的程序来分离这两种形式的铬,我们没有单独测定 Cr(III)和危害更大的 Cr(VI)。

相似文献

[1]
Toxic element contaminations of prenatal vitamins.

Toxicol Appl Pharmacol. 2023-10-15

[2]
Heavy metal contamination of prenatal vitamins.

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[3]
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[4]
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[6]
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[7]
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[8]
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[9]
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引用本文的文献

[1]
Content of selected nutrients and heavy metals in prenatal multivitamins and minerals: an observational study.

Am J Clin Nutr. 2025-6

本文引用的文献

[1]
Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight.

Environ Health. 2022-7-14

[2]
Heavy metal contamination of prenatal vitamins.

Toxicol Rep. 2018-3-6

[3]
The importance of boron in biological systems.

J Trace Elem Med Biol. 2017-10-26

[4]
Nothing Boring About Boron.

Integr Med (Encinitas). 2015-8

[5]
Association of arsenic with adverse pregnancy outcomes/infant mortality: a systematic review and meta-analysis.

Environ Health Perspect. 2015-5

[6]
Levels of heavy metals and trace elements in umbilical cord blood and the risk of adverse pregnancy outcomes: a population-based study.

Biol Trace Elem Res. 2014-9

[7]
Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children.

J Expo Sci Environ Epidemiol. 2014

[8]
The influence of surface charge and photo-reactivity on skin-permeation enhancer property of nano-TiO₂ in ex vivo pig skin model under indoor light.

Int J Pharm. 2014-3-29

[9]
90-Day subchronic toxicity study of sodium molybdate dihydrate in rats.

Regul Toxicol Pharmacol. 2014-12

[10]
Titanium hypersensitivity. A hidden threat for dental implant patients?

N Y State Dent J. 2013

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