Key Laboratory of Medical Cell Biology in Inner Mongolia, Clinical Medical Research Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China.
Department of Gastrointestinal Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China.
Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126611. doi: 10.1016/j.ijbiomac.2023.126611. Epub 2023 Aug 29.
There are many studies on specific macromolecules and their contributions to tissue repair. Macromolecules have supporting and protective effects in organisms and can help regrow, reshape, and promote self-repair and regeneration of damaged tissues. Macromolecules, such as proteins, nucleic acids, and polysaccharides, can be constructed into hydrogels for the preparation of slow-release drug agents, carriers for cell culture, and platforms for gene delivery. Hydrogels and microspheres are fabricated by chemical crosslinking or mixed co-deposition often used as scaffolds, drug carriers, or cell culture matrix, provide proper mechanical support and nutrient delivery, a well-conditioned environment that to promote the regeneration and repair of damaged tissues. This review provides a comprehensive overview of recent developments in the construction of macromolecules into hydrogels and microspheres based on the proteins, nucleic acids, polysaccharides and other polymer and their application in tissue repair. We then discuss the latest research trends regarding the advantages and disadvantages of these composites in repair tissue. Further, we examine the applications of microspheres/hydrogels in different tissue repairs, such as skin tissue, cartilage, tumor tissue, synovial, nerve tissue, and cardiac repair. The review closes by highlighting the challenges and prospects of microspheres/hydrogels composites.
有许多关于特定大分子及其对组织修复贡献的研究。大分子在生物体中具有支持和保护作用，可以帮助受损组织的再生、重塑和促进自我修复和再生。蛋白质、核酸和多糖等大分子可以构建成水凝胶，用于制备缓控释药物制剂、细胞培养载体和基因传递平台。水凝胶和微球通常通过化学交联或混合共沉积来制备，可用作支架、药物载体或细胞培养基质，提供适当的机械支撑和营养输送，为受损组织的再生和修复提供良好的条件环境。本文综述了近年来基于蛋白质、核酸、多糖等聚合物将大分子构建成水凝胶和微球的最新进展及其在组织修复中的应用。我们讨论了这些复合材料在修复组织中的优缺点的最新研究趋势。此外，我们还研究了微球/水凝胶在不同组织修复中的应用，如皮肤组织、软骨、肿瘤组织、滑膜、神经组织和心脏修复。最后，本文强调了微球/水凝胶复合材料的挑战和前景。
