Engineering Research Center for Waste Oil Recovery Technology and Equipment, Ministry of Education, Chongqing Technology and Business University, Chongqing 400067, PR China.
School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, PR China; Chongqing Key Laboratory of Medicinal Chemistry & Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, PR China.
Int J Biol Macromol. 2022 Aug 1;214:480-491. doi: 10.1016/j.ijbiomac.2022.06.137. Epub 2022 Jun 24.
There are many different grafts to repair damaged tissue. Various types of biological scaffolds, including films, fibers, microspheres, and hydrogels, can be used for tissue repair. A hydrogel, which is composed a natural or synthetic polymer network with high water absorption capacity, can provide a microenvironment closely resembling the extracellular matrix (ECM) of natural tissues to stimulate cell adhesion, proliferation, and differentiation. It has been shown to have great application potential in the field of tissue repair and regeneration. Hydrogels derived from natural tissues retain a variety of proteins and growth factors in optimal proportions, which is beneficial for the regeneration of specific tissues. This article reviews the latest research advances in the field of hydrogels from a variety of natural tissue sources, including bone tissue, blood vessels, nerve tissue, adipose tissue, skin tissue, and muscle tissue, including preparation methods, advantages, and applications in tissue engineering and regenerative medicine. Finally, it summarizes and discusses the challenges faced by natural tissue-derived hydrogels used in tissue repair, as well as future research and application directions.
有许多不同的移植物可用于修复受损组织。各种类型的生物支架，包括膜、纤维、微球和水凝胶，可用于组织修复。水凝胶由具有高吸水性的天然或合成聚合物网络组成，可为细胞黏附、增殖和分化提供类似于天然组织细胞外基质（ECM）的微环境。它在组织修复和再生领域具有巨大的应用潜力。源自天然组织的水凝胶保留了多种蛋白质和生长因子的最佳比例，有利于特定组织的再生。本文综述了不同天然组织来源的水凝胶（包括骨组织、血管、神经组织、脂肪组织、皮肤组织和肌肉组织）在组织工程和再生医学中的最新研究进展，包括制备方法、优点和应用。最后，总结并讨论了用于组织修复的天然组织衍生水凝胶所面临的挑战以及未来的研究和应用方向。
