在门诊环境中对圆锥角膜和角膜扩张症进行角膜交联术时感染性角膜炎及其他眼表不良事件的发生率：一项回顾性队列研究。
Rates of infectious keratitis and other ocular surface adverse events in corneal cross-linking for keratoconus and corneal ectasias performed in an office-based setting: a retrospective cohort study.
作者信息
Hafezi Farhad, Torres-Netto Emilio A, Kollros Leonard, Lu Nan-Ji, Hafezi Nikki, Mazzotta Cosimo, Aydemir M Enes, Hillen Mark
机构信息
Laboratory for Ocular Cell Biology, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland.
ELZA Institute, Dietikon, Switzerland.
出版信息
Eye Vis (Lond). 2023 Sep 1;10(1):36. doi: 10.1186/s40662-023-00354-1.
BACKGROUND
This study aimed to compare the complication rates of epithelium-off corneal cross-linking (epi-off CXL) performed in an office-based setting with those of epi-off CXL performed in an operating room.
METHODS
A retrospective cohort study, comprising 501 consecutive epi-off CXL procedures, performed in a non-sterile procedure room without laminar flow ventilation at the ELZA Institute in Zurich, Switzerland, between November 2015 and October 2021, was conducted.
RESULTS
No cases of postoperative infectious keratitis were observed, while sterile infiltrates occurred in 10 out of 501 (2.00%) patients, all of whom responded well to topical steroid therapy. Delayed epithelialization (> 7 days) occurred in 14 out of 501 (2.79%) patients. No other adverse events were noted.
CONCLUSIONS
Office-based epi-off CXL does not appear to be associated with an increased risk of complications when compared to operating room settings.
背景
本研究旨在比较在门诊环境中进行的去上皮角膜交联术（epi-off CXL）与在手术室中进行的epi-off CXL的并发症发生率。
方法
进行了一项回顾性队列研究，纳入了2015年11月至2021年10月期间在瑞士苏黎世的ELZA研究所的非无菌、无层流通风的手术室内连续进行的501例epi-off CXL手术。
结果
未观察到术后感染性角膜炎病例，501例患者中有10例（2.00%）出现无菌性浸润，所有患者局部使用类固醇治疗后反应良好。501例患者中有14例（2.79%）出现上皮化延迟（>7天）。未发现其他不良事件。
结论
与手术室环境相比，门诊epi-off CXL似乎不会增加并发症风险。
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