McGirr Samantha, Andersen Dallin, Halgren John
Department of Ophthalmology, Truhlsen Eye Institute at the University of Nebraska Medical Center, 3902 Leavenworth St, Omaha, NE, 68105, USA.
Am J Ophthalmol Case Rep. 2020 Jan 31;17:100616. doi: 10.1016/j.ajoc.2020.100616. eCollection 2020 Mar.
To report a case of fungal keratitis after corneal collagen crosslinking (CXL) surgery.
We report a case of fungal keratitis after CXL for post-refractive surgery ectasia. The patient presented 12 days after surgery with a corneal ulcer that was culture positive for species of fungus. She subsequently developed a bacterial superinfection. The keratitis resolved with medical therapy, although the patient required a penetrating keratoplasty (PKP) due to central corneal scarring.
To our knowledge, this is the first case of fungal keratitis as a complication after CXL in the United States and the first case of infection after CXL using the Dresden protocol. Infectious keratitis is a rare but serious complication of CXL, and we suggest continued innovation of operative techniques that may reduce the risk of infectious keratitis.
报告1例角膜胶原交联（CXL）手术后发生真菌性角膜炎的病例。
我们报告1例因屈光手术后角膜扩张而行CXL术后发生真菌性角膜炎的病例。患者术后12天出现角膜溃疡，真菌培养阳性。随后她发生了细菌二重感染。尽管患者因中央角膜瘢痕需要行穿透性角膜移植术（PKP），但经药物治疗后角膜炎得以消退。
据我们所知，这是美国首例CXL术后发生真菌性角膜炎的病例，也是首例使用德累斯顿方案行CXL术后发生感染的病例。感染性角膜炎是CXL罕见但严重的并发症，我们建议持续创新手术技术以降低感染性角膜炎的风险。
