Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Center for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Front Endocrinol (Lausanne). 2020 Nov 25;11:567959. doi: 10.3389/fendo.2020.567959. eCollection 2020.
To investigate the association between serum adiponectin levels and diabetic peripheral neuropathy (DPN) in Chinese type 2 diabetes (T2D) patients.
Two hundred nineteen T2D patients aged 40-79 years were divided into two groups according to whether they had DPN. The systemic levels of five biomarkers were measured using a human adipokine multiplexed bead-based immunoassay. Diabetic peripheral neuropathy diagnostic criteria included both common DPN symptoms and neurological screening tests.
Most features of DPN (=98) and non-DPN patients (=121) are similar, but the DPN patients were slightly older, had longer diabetes duration, higher hemoglobin (Hb) A1c, lower estimated glomerular filtration rates (eGFR), less exercise, and used lipid-lowering drugs more often. Serum adiponectin levels of DPN patients were higher than that of non-DPN patients (8.13 . 9.63 mg/ml, = 0.004). Serum adiponectin levels were positively associated with DPN after adjusting for age, gender, body mass index, hypertension, HbA1c, alcohol intake, smoking status, physical activity, log-transformed low density lipoprotein cholesterol, lipid-lowering drug usage, eGFR, and diabetes duration {odds ratio (OR) 1.72 [95% confidence interval (CI) 1.02-2.89], = 0.041}. The OR refers to a doubling in biomarkers.
Serum adiponectin levels were higher in DPN patients compared to non‑DPN patients in this Chinese T2D population. Serum adiponectin levels were positively associated with DPN presence, independent of multiple confounders.
探讨中国 2 型糖尿病（T2D）患者血清脂联素水平与糖尿病周围神经病变（DPN）的关系。
将 219 名年龄在 40-79 岁的 T2D 患者根据是否患有 DPN 分为两组。采用人脂联素多指标 bead 免疫分析试剂盒测量五种生物标志物的系统水平。DPN 的诊断标准包括常见 DPN 症状和神经学筛查测试。
大多数 DPN（=98）和非 DPN（=121）患者的特征相似，但 DPN 患者年龄稍大，糖尿病病程较长，糖化血红蛋白（HbA1c）较高，估算肾小球滤过率（eGFR）较低，运动较少，降脂药物使用频率较高。DPN 患者的血清脂联素水平高于非 DPN 患者（8.13 ± 9.63 mg/ml，= 0.004）。在校正年龄、性别、体重指数、高血压、HbA1c、饮酒、吸烟状况、体力活动、低密度脂蛋白胆固醇对数转换、降脂药物使用、eGFR 和糖尿病病程后，血清脂联素水平与 DPN 呈正相关（优势比[OR]1.72 [95%置信区间[CI]1.02-2.89]，= 0.041）。OR 指的是生物标志物增加一倍。
与非 DPN 患者相比，中国 T2D 人群中 DPN 患者的血清脂联素水平更高。在调整了多种混杂因素后，血清脂联素水平与 DPN 的发生呈正相关。
