血清内皮细胞蛋白作为肥胖儿科患者心血管风险的预测性生物标志物。
Serum endocan as a predictive biomarker of cardiovascular risk in obese pediatric patients.
机构信息
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Department of Human Pathology of Adulthood and Childhood, Unit of Pediatrics, University of Messina, Via Consolare Valeria 98126, Messina, Italy.
出版信息
Ital J Pediatr. 2023 Aug 31;49(1):108. doi: 10.1186/s13052-023-01510-y.
BACKGROUND
Endocan is a soluble dermatan sulfate proteoglycan (50 kDa) secreted by endothelial cells and expressed by dermal, coronary, pulmonary and adipose tissue microvasculature. It plays an important role in the pathogenesis of vascular disorders, inflammatory state, endothelium dysfunction and neoangiogenesis. Aims of the study were to compare fasting serum endocan levels between children with obesity and healthy controls and to investigate the relationships between endocan, body mass index (BMI) and other indices of cardiometabolic risk.
METHODS
This single-center, observational, retrospective study included 19 pediatric patients with obesity aged 11.94 ± 0.52 years and 19 lean matched controls. Each patient underwent clinical and auxological examination and laboratory investigations including routine organs function tests and lipid profile. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Fasting endocan serum levels were measured using an enzyme-linked immunosorbent assay (ELISA).
RESULTS
Compared to healthy subjects, serum endocan levels were found to be significantly upraised in children with obesity. Endocan resulted significantly correlated with insulin levels (rho 0.47; p = 0.04); in addition, an association with HOMA-IR values with a trend toward the statistical significance (rho 0.43; p = 0.07) was found. No significant correlation with fasting blood glucose values and lipid serum levels was demonstrated. Although not statistically significant, a correlation between endocan and the presence and grading of liver steatosis on ultrasound (rho 0.51; p = 0.08 and rho 0.51; p = 0.08, respectively) was found.
CONCLUSIONS
These findings confirm the association between endothelial damage and insulin resistance in children with obesity. Endocan could be used as a biomarker of early endothelial dysfunction in children with obesity and could be a valid predictor of future cardiovascular risk in adulthood.
背景
Endocan 是一种可溶性硫酸皮肤素蛋白聚糖（50 kDa），由内皮细胞分泌，并由皮肤、冠状动脉、肺和脂肪组织微血管表达。它在血管疾病的发病机制、炎症状态、内皮功能障碍和新血管生成中起着重要作用。本研究的目的是比较肥胖儿童和健康对照组的空腹血清 Endocan 水平，并探讨 Endocan 与体重指数（BMI）和其他心血管代谢风险指标之间的关系。
方法
这是一项单中心、观察性、回顾性研究，纳入了 19 名年龄为 11.94±0.52 岁的肥胖儿童患者和 19 名匹配的健康对照者。每位患者均接受临床和体格检查以及实验室检查，包括常规器官功能检查和血脂谱。计算胰岛素抵抗的稳态模型评估（HOMA-IR）。使用酶联免疫吸附试验（ELISA）测量空腹血清 Endocan 水平。
结果
与健康受试者相比，肥胖儿童的血清 Endocan 水平明显升高。Endocan 与胰岛素水平呈显著相关（rho 0.47；p=0.04）；此外，还发现与 HOMA-IR 值存在关联，具有统计学意义的趋势（rho 0.43；p=0.07）。与空腹血糖值和血脂血清水平无显著相关性。尽管无统计学意义，但发现 Endocan 与超声检查中肝脏脂肪变性的存在和分级之间存在相关性（rho 0.51；p=0.08 和 rho 0.51；p=0.08）。
结论
这些发现证实了肥胖儿童的内皮损伤与胰岛素抵抗之间的关联。Endocan 可作为肥胖儿童早期内皮功能障碍的生物标志物，并可作为成年后未来心血管风险的有效预测指标。
Zotero 插件