Augustin Matthias, Lindner Lisa, Kühl Laura, Weiss Anja, Rustenbach Stephan Jeff, Stephan Brigitte, Feuchtenberger Martin, Mrowietz Ulrich, Thaçi Diamant, Staubach Petra, Baraliakos Xenofon, Strangfeld Anja, von Kiedrowski Ralph, Behrens Frank, Regierer Anne Constanze
Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
German Rheumatism Research Center, Epidemiology Unit, Berlin, Germany.
J Dtsch Dermatol Ges. 2023 Oct;21(10):1170-1176. doi: 10.1111/ddg.15178. Epub 2023 Aug 31.
Psoriatic arthritis (PsA) is a chronic systemic inflammatory disease affecting the musculoskeletal system, skin and nails. The aim is to characterize sociodemographic and clinical patient profiles documented in dermatologic and rheumatologic care.
Data of 704 patients with PsA from the dermatological Psoriasis Registry PsoBest (PB) and 1066 patients from the rheumatological disease registry RABBIT-SpA (RS) were analyzed. Comparable anamnestic and clinical variables were identified and descriptively analyzed.
The mean age was 51.7 years in PB and 51.9 in RS. Disease duration of psoriasis was longer, mean cutaneous severity was higher in PB. However, more patients in RS vs. PB had tender joints and swollen joints. Mean Dermatology Life Quality Index was higher in PB and mean Health Assessment Questionnaire in RS. Patient reported global disease activity and pain were lower in PB. IL-23 inhibitors were used more frequently in PB, and TNF inhibitors in RS.
Clinical specialization was associated with different clinical and treatment patterns of PsA. This may indicate a selection by dominant manifestation of psoriatic disease and potentially by effects of health care access. Psoriatic arthritis should be treated in a multidisciplinary approach considering all facets of this complex disease.
银屑病关节炎（PsA）是一种影响肌肉骨骼系统、皮肤和指甲的慢性全身性炎症性疾病。目的是描述皮肤科和风湿科护理中记录的社会人口统计学和临床患者特征。
分析了来自皮肤科银屑病登记处PsoBest（PB）的704例PsA患者和来自风湿病登记处RABBIT-SpA（RS）的1066例患者的数据。确定了可比的既往史和临床变量并进行描述性分析。
PB组的平均年龄为51.7岁，RS组为51.9岁。银屑病的病程更长，PB组的平均皮肤严重程度更高。然而，与PB组相比，RS组有更多患者出现压痛关节和肿胀关节。PB组的平均皮肤病生活质量指数更高，RS组的平均健康评估问卷得分更高。患者报告的总体疾病活动度和疼痛在PB组更低。PB组更频繁使用IL-23抑制剂，RS组更频繁使用TNF抑制剂。
临床专科化与PsA不同的临床和治疗模式相关。这可能表明是根据银屑病疾病的主要表现以及可能的医疗保健可及性影响进行的选择。银屑病关节炎应采用多学科方法进行治疗，同时考虑这种复杂疾病的各个方面。
