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瓜蒌逍遥汤联合无痛通乳手法治疗哺乳期急性乳腺炎、乳腺脓肿的临床疗效:一项观察性研究。

Clinical efficacy of Gualou Xiaoyong Decoction and painless lactation manipulation in treating lactation acute mastitis and breast abscess: An observational study.

机构信息

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, China.

Department of Orthopaedics, Hangzhou Red Cross Hospital, Hangzhou, China.

出版信息

Medicine (Baltimore). 2023 Aug 25;102(34):e34617. doi: 10.1097/MD.0000000000034617.

Abstract

Information on the effects of Chinese medicine in the treatment of lactational acute mastitis and breast abscess is limited; thus, we conducted an observational study to analyze the clinical efficacy of Gualou Xiaoyong Decoction combined with painless lactation manipulation in the treatment of lactational acute mastitis and breast abscess. A total of 41 patients with lactational acute mastitis and breast abscess who were treated with Gualou Xiaoyong Decoction and painless lactation manipulation from October 2021 to October 2022 were included in this study. The age, fetal times(primiparous/multiparous), delivery mode (cesarean section/vaginal delivery), onset time, breast lump diameter, skin rash diameter, body temperature, visual analogue score, blood routine, C-reactive protein, procalcitonin, bacterial culture in milk, B ultrasound and other data of these patients were statistically analyzed. After treatment, the breast lump diameter of these patients decreased significantly, the skin rash diameter was reduced or disappeared, the body temperature decreased or returned to a normal range, and the visual analogue score also decreased. Besides, these patients had a decreased total number of white blood cells and a reduced percentage of neutrophils, C-reactive protein, and procalcitonin after treatment. In addition, bacteria in the milk of most patients disappeared, and there was no abnormality in B ultrasonic imaging. Except for 2 patients with breast abscess who stopped breastfeeding on the affected side for 1 day and 3 days respectively, all other patients continued to provide breast milk for their infants, and no adverse reactions were observed in these infants. The combination of Gualou Xiaoyong Decoction and painless lactation manipulation can achieve favorable clinical effects in the treatment of lactational acute mastitis and breast abscess. This combined therapy has good efficacy, short course of treatment, low costs, and great convenience with the avoidance of pain, hospitalization, influence on lactation, breast scar and other adverse outcomes.

摘要

关于中药在哺乳期急性乳腺炎和乳腺脓肿治疗中的作用的信息有限;因此,我们进行了一项观察性研究,以分析瓜蒌消痈汤联合无痛通乳手法治疗哺乳期急性乳腺炎和乳腺脓肿的临床疗效。本研究共纳入 2021 年 10 月至 2022 年 10 月采用瓜蒌消痈汤联合无痛通乳手法治疗的哺乳期急性乳腺炎和乳腺脓肿患者 41 例。对这些患者的年龄、胎次(初产妇/经产妇)、分娩方式(剖宫产/阴道分娩)、发病时间、乳房肿块直径、皮肤红肿直径、体温、视觉模拟评分、血常规、C 反应蛋白、降钙素原、乳汁细菌培养、B 超等数据进行了统计分析。治疗后,这些患者的乳房肿块直径明显缩小,皮肤红肿直径缩小或消失,体温降低或恢复正常范围,视觉模拟评分也降低。此外,这些患者治疗后白细胞总数减少,中性粒细胞百分比降低,C 反应蛋白和降钙素原降低。此外,大多数患者乳汁中的细菌消失,B 超影像学无异常。除了 2 例乳腺脓肿患者分别停止在患侧哺乳 1 天和 3 天外,其余患者均继续为婴儿提供母乳喂养,婴儿未出现不良反应。瓜蒌消痈汤联合无痛通乳手法治疗哺乳期急性乳腺炎和乳腺脓肿可取得良好的临床效果。这种联合治疗具有疗效好、疗程短、费用低、操作方便等优点,可避免疼痛、住院、影响哺乳、乳房疤痕等不良后果。

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本文引用的文献

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Treatments for breast abscesses in breastfeeding women.哺乳期妇女乳房脓肿的治疗方法。
Cochrane Database Syst Rev. 2015 Aug 17;2015(8):CD010490. doi: 10.1002/14651858.CD010490.pub2.
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Inflammatory mediators in mastitis and lactation insufficiency.乳腺炎和泌乳不足中的炎症介质。
J Mammary Gland Biol Neoplasia. 2014 Jul;19(2):161-7. doi: 10.1007/s10911-014-9325-9. Epub 2014 Jun 25.

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