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早期运动对心力衰竭患者心功能及脂代谢通路的影响。

Effects of early exercise on cardiac function and lipid metabolism pathway in heart failure.

机构信息

Department of Internal Medicine, Botucatu Medical School, São Paulo State University, Botucatu, Brazil.

Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.

出版信息

J Cell Mol Med. 2023 Oct;27(19):2956-2969. doi: 10.1111/jcmm.17908. Epub 2023 Aug 31.

Abstract

We employed an early training exercise program, immediately after recovery from surgery, and before severe cardiac hypertrophy, to study the underlying mechanism involved with the amelioration of cardiac dysfunction in aortic stenosis (AS) rats. As ET induces angiogenesis and oxygen support, we aimed to verify the effect of exercise on myocardial lipid metabolism disturbance. Wistar rats were divided into Sham, trained Sham (ShamT), AS and trained AS (AST). The exercise consisted of 5-week sessions of treadmill running for 16 weeks. Statistical analysis was conducted by anova or Kruskal-Wallis test and Goodman test. A global correlation between variables was also performed using a two-tailed Pearson's correlation test. AST rats displayed a higher functional capacity and a lower cardiac remodelling and dysfunction when compared to AS, as well as the myocardial capillary rarefaction was prevented. Regarding metabolic properties, immunoblotting and enzymatic assay raised beneficial effects of exercise on fatty acid transport and oxidation pathways. The correlation assessment indicated a positive correlation between variables of angiogenesis and FA utilisation, as well as between metabolism and echocardiographic parameters. In conclusion, early exercise improves exercise tolerance and attenuates cardiac structural and functional remodelling. In parallel, exercise attenuated myocardial capillary and lipid metabolism derangement in rats with aortic stenosis-induced heart failure.

摘要

我们采用早期训练方案,即在手术后恢复和严重心肌肥厚之前,研究主动脉瓣狭窄(AS)大鼠心脏功能障碍改善所涉及的潜在机制。由于 ET 可诱导血管生成和氧支持,我们旨在验证运动对心肌脂质代谢紊乱的影响。Wistar 大鼠分为假手术组(Sham)、训练假手术组(ShamT)、AS 组和训练 AS 组(AST)。运动方案包括 16 周 5 周的跑步机跑步。统计分析采用单因素方差分析或 Kruskal-Wallis 检验和 Goodman 检验。还使用双尾 Pearson 相关检验对变量进行了全局相关性分析。与 AS 相比,AST 大鼠表现出更高的功能能力和更低的心脏重塑和功能障碍,并且预防了心肌毛细血管稀疏。关于代谢特性,免疫印迹和酶测定显示运动对脂肪酸转运和氧化途径有有益的影响。相关性评估表明,血管生成和 FA 利用的变量之间存在正相关,以及代谢和超声心动图参数之间存在正相关。总之,早期运动可提高运动耐量,减轻心脏结构和功能重塑。同时,运动可减轻主动脉瓣狭窄引起心力衰竭大鼠的心肌毛细血管和脂质代谢紊乱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3abc/10538274/43d8505d71ea/JCMM-27-2956-g006.jpg

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