Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cancer Sci. 2023 Nov;114(11):4433-4444. doi: 10.1111/cas.15941. Epub 2023 Aug 31.
Previous research has shown that adhering to the Eat-Lancet diet (ELD) is associated with a lower risk of chronic diseases and mortality. However, the associations between ELD and lung cancer incidence and mortality are unclear. To address this gap, we conducted a prospective cohort study involving 101,755 adults from the Prostate, Lung, Colorectal, and Ovarian (PLCO) trial in the USA. The ELD score was utilized to assess compliance with the ELD, with higher scores indicating greater compliance. We employed Cox regression analyses to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of ELD score with the incidence and mortality of lung cancer and its subtypes. In addition, sensitivity analyses were performed to ensure the robustness of our findings. In total, 1706 cases of lung cancer and 1217 lung cancer-associated deaths were recorded during the study period. Our analysis revealed that higher ELD scores were significantly associated with a reduced incidence (HR vs. : 0.73; 95% CI: 0.60, 0.89; p = 0.001) and mortality (HR : 0.74; 95% CI: 0.59, 0.93; p = 0.005) of lung cancer in a dose-response manner (all p > 0.05). The reliability of these results was supported by sensitivity analyses. Notably, these associations were primarily observed in non-small-cell lung cancer. In conclusion, our findings suggest that adherence to the ELD may be associated with a reduced risk of lung cancer incidence and mortality.
先前的研究表明，坚持柳叶刀饮食（ELD）与较低的慢性病和死亡率风险相关。然而，ELD 与肺癌发病率和死亡率之间的关联尚不清楚。为了解决这一差距，我们进行了一项前瞻性队列研究，涉及来自美国前列腺癌、肺癌、结直肠癌和卵巢癌（PLCO）试验的 101755 名成年人。使用 ELD 评分来评估对 ELD 的遵守情况，得分越高表示遵守程度越高。我们采用 Cox 回归分析计算 ELD 评分与肺癌及其亚型发病率和死亡率的风险比（HR）和 95%置信区间（CI）。此外，还进行了敏感性分析以确保我们发现的稳健性。在研究期间，共记录了 1706 例肺癌病例和 1217 例肺癌相关死亡。我们的分析表明，较高的 ELD 评分与肺癌发病率（HR 比：0.73；95%CI：0.60，0.89；p = 0.001）和死亡率（HR 比：0.74；95%CI：0.59，0.93；p = 0.005）显著相关呈剂量反应关系（所有 p 均>0.05）。敏感性分析支持了这些结果的可靠性。值得注意的是，这些关联主要在非小细胞肺癌中观察到。总之，我们的研究结果表明，坚持 ELD 可能与降低肺癌发病率和死亡率的风险相关。
