Giampietro O, Moggi G, Chisci R, Coluccia A, Luche A D, Simonini N, Brunori I
J Clin Endocrinol Metab. 1979 Jul;49(1):141-3. doi: 10.1210/jcem-49-1-141.
We studied PRL, FSH, and LH response to LRH in 82 anovulatory and 4 normally ovulating women. Ten anovulatory patients who were basally hyperprolactinemic showed no significant change in PRL concentration after LRH. Of the remaining 72 anovulatory patients with basal PRL levels in the normal range, 59 showed no PRL modification after LRH (as in normals) whereas in 13 patients, a prompt and significant rise of PRL concentration above basal levels in response to LRH was observed. In these 13 patients, the basal PRL levels were significantly higher than those of the other 59 normoprolactinemic women. No significant differences in gonadotropin concentrations were detected among the three groups. The unusual rise in PRL levels after LRH in these 13 patients can be interpreted as a paradoxical response of the pituitary to a specific stimulus, as seen in other clinical conditions. It is suggested that this phasic hyperprolactinemia might represent an intermediate phase between true normoprolactinemia and chronic hyperprolactinemia.
我们研究了82名无排卵女性和4名正常排卵女性对促黄体激素释放激素（LRH）的催乳素（PRL）、促卵泡生成素（FSH）及促黄体生成素（LH）反应。10名基础催乳素水平高的无排卵患者在注射LRH后PRL浓度无显著变化。其余72名基础PRL水平在正常范围的无排卵患者中，59名患者在注射LRH后PRL无变化（与正常情况相同），而13名患者在注射LRH后出现PRL浓度迅速且显著高于基础水平的升高。在这13名患者中，基础PRL水平显著高于其他59名催乳素水平正常的女性。三组之间促性腺激素浓度未检测到显著差异。这13名患者在注射LRH后PRL水平异常升高可解释为垂体对特定刺激的矛盾反应，正如在其他临床情况中所见。提示这种阶段性高催乳素血症可能代表真正的催乳素水平正常和慢性高催乳素血症之间的中间阶段。
