Couture-Lapointe Camille, Grenier Pierre-Olivier, Bessette Louis, Veillette Hélène
Division of Dermatology, CHU de Québec, Laval University, Quebec, QC, Canada.
Dermatology Department, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
SAGE Open Med Case Rep. 2023 Aug 25;11:2050313X231195480. doi: 10.1177/2050313X231195480. eCollection 2023.
The differential diagnosis for chronic cutaneous ulcers is wide. Once the common causes have been excluded, infrequent ones, including drugs, should be considered. We report the case of a 67 year old woman with multiple ulcers not responding to conventional treatment. Multiple investigations including laboratory testing, skin biopsies and tissue cultures were negative. A few cases of leflunomide-induced cutaneous ulcers are reported in the literature. Our patient was on this drug for 12 years. Discontinuation of leflunomide led to ulcers resolution. This is the longest reported time interval between leflunomide initiation and ulceration onset.
慢性皮肤溃疡的鉴别诊断范围很广。一旦排除了常见病因，就应考虑包括药物在内的罕见病因。我们报告了一例67岁女性患者，其多处溃疡对传统治疗无反应。包括实验室检查、皮肤活检和组织培养在内的多项检查均为阴性。文献中报道了几例来氟米特诱发的皮肤溃疡病例。我们的患者服用该药已达12年。停用来氟米特后溃疡得以愈合。这是文献报道中来氟米特开始使用至溃疡发作之间最长的时间间隔。
