Jakob Antje, Porstmann Romy, Rompel Rainer
Department of Dermatology, Kassel, Germany.
J Dtsch Dermatol Ges. 2006 Apr;4(4):324-7. doi: 10.1111/j.1610-0387.2006.05934.x.
Leflunomide is a disease-modifying antirheumatic drug for the treatment of active rheumatoid arthritis and psoriatic arthritis. Skin ulcerations are not listed as a side effect for this drug, and there has been only one case report on leflunomide associated skin ulcerations. We report on two females, 59 and 63 years old respectively, who were treated with leflunomide for rheumatoid arthritis and subsequently developed severe skin ulcerations. After discontinuation of the drug the skin ulcerations healed complete even if very slowly.
来氟米特是一种改善病情的抗风湿药物，用于治疗活动性类风湿关节炎和银屑病关节炎。皮肤溃疡未被列为该药的副作用，关于来氟米特相关皮肤溃疡仅有一例病例报告。我们报告了两名分别为59岁和63岁的女性，她们因类风湿关节炎接受来氟米特治疗，随后出现了严重的皮肤溃疡。停药后，皮肤溃疡即使愈合得非常缓慢，但仍完全愈合。
