Sakamoto Ryo, Hida Yukariko, Shiozaki Mariko, Motooka Hiroko, Koyama Atsuko
Psychosomatic Medicine, Kindai University Faculty of Medicine, Osakasayama City, JPN.
Palliative Care, Centre for Palliative Care, Kindai University Hospital, Osakasayama City, JPN.
Cureus. 2023 Jul 31;15(7):e42760. doi: 10.7759/cureus.42760. eCollection 2023 Jul.
Cancer survivors have reduced health-related quality of life (HRQOL) due to impaired daily functioning. In addition, daily stress leads to worsening oxidative stress. The purpose of this study is to investigate the efficacy of laughter therapy on HRQOL and oxidative stress in cancer survivors.
This before-and-after study asked cancer survivors to watch a 15-minute or longer comedy video over a four-week period to assess the Functional Assessment of Cancer Therapy-General (FACT-G), EuroQOL 5 dimension 3-level (EQ-5D-3L), Hospital Anxiety and Depression Scale (HADS), biological Antioxidant Potential (BAP), Reactive Oxygen Metabolites-derived compounds (d-ROMs), Oxidative Stress Index (OSI), and the antioxidant/oxidative stress ratio.
The nonparametric Friedman test showed significant increases from baseline in FACT-G and EQ-VAS scores and significant decreases in HADS-Anxiety and HADS-Depression scores. Post hoc analyses showed that these items commonly differed significantly at baseline versus three and four weeks after Bonferroni correction. T-test results in the biological analysis revealed small and moderate effects with significant differences in BAP (p < 0.01, d = 0.49), OSI (p = 0.03, d = 0.33), and BAP/d-ROMs (p < 0.01, d = 0.51).
These results suggest that daily comedy viewing may be an effective intervention to improve quality of life and antioxidant capacity in cancer survivors. Considering its safety, convenience, and low cost, it should be considered a high-value intervention for cancer survivors.
癌症幸存者由于日常功能受损，其健康相关生活质量（HRQOL）有所下降。此外，日常压力会导致氧化应激加剧。本研究的目的是调查笑疗法对癌症幸存者的健康相关生活质量和氧化应激的疗效。
这项前后对照研究要求癌症幸存者在四周时间内观看一段15分钟或更长时间的喜剧视频，以评估癌症治疗通用功能评估量表（FACT-G）、欧洲五维度健康量表3级（EQ-5D-3L）、医院焦虑抑郁量表（HADS）、生物抗氧化潜能（BAP）、活性氧代谢产物衍生化合物（d-ROMs）、氧化应激指数（OSI）以及抗氧化/氧化应激比值。
非参数Friedman检验显示，FACT-G和EQ-VAS评分较基线有显著提高，HADS焦虑和HADS抑郁评分显著降低。事后分析表明，在Bonferroni校正后，这些项目在基线与三周和四周后通常有显著差异。生物学分析中的t检验结果显示有小到中等程度的效应，BAP（p < 0.01，d = 0.49）、OSI（p = 0.03，d = 0.33）和BAP/d-ROMs（p < 0.01，d = 0.51）有显著差异。
这些结果表明，每天观看喜剧可能是一种有效的干预措施，可改善癌症幸存者的生活质量和抗氧化能力。考虑到其安全性、便利性和低成本，它应被视为癌症幸存者的一种高价值干预措施。
