Chauhan Ashutosh, Semwal Deepak Kumar, Semwal Ruchi Badoni, Joshi Sunil Kumar, Adhana Rajesh Kumar, Goswami Madhavi Sanjay
Department of Biotechnology, Faculty of Biomedical Sciences, Uttarakhand Ayurved University, Dehradun, Uttarakhand, India.
Department of Phytochemistry, Faculty of Biomedical Sciences, Uttarakhand Ayurved University, Dehradun, Uttarakhand, India.
Ayu. 2022 Apr-Jun;43(2):35-44. doi: 10.4103/ayu.AYU_7_20. Epub 2023 Aug 2.
The prevalence of type 2 diabetes (T2D) has increased substantially in the past few decades throughout the world. In India, the epidemic of diabetes continues to increase irrespective of area, status, and age. Despite various scientific societies involved in the treatment of diabetes, still, the burden of diabetes keeps growing.
The aim of this work is to explore the Ayurvedic concept of a personalized diet to modulate the gut microbiota for the treatment of T2D.
A thorough study of literature from online scientific databases including Web of Science, PubMed, Scopus, and Google Scholar as well as from classical texts of Ayurveda was done. A careful compilation was done to extract the valuable output of the personalized diet to modulate the gut microbiota.
There are various diets used to control blood glucose levels, and their effects are also being studied on the transcriptome or epigenome despite 99.9% genomic similarity among human beings. However, microbiomes have only 10% similarity. Ayurvedic diet is given on the basis of (body constitution), therefore, it is also called personalized diet.
The diets prescribed for T2D in Ayurveda are high in fibers, polyphenols, and complex carbohydrates which enrich butyrate-producing bacteria and decrease lipopolysaccharide-producing bacteria. Hence, there is a need to have a personalized diet to manage the glucose level by enriching beneficial gut microbiota. The approach of a personalized diet associated with gut microbiota can be helpful in maintaining blood sugar in T2D patients.
在过去几十年中，2型糖尿病（T2D）在全球的患病率大幅上升。在印度，无论地区、地位和年龄，糖尿病的流行都在持续增加。尽管有各种科学学会参与糖尿病的治疗，但糖尿病的负担仍在不断加重。
本研究旨在探索阿育吠陀个性化饮食概念，通过调节肠道微生物群来治疗T2D。
对包括科学网、PubMed、Scopus和谷歌学术在内的在线科学数据库以及阿育吠陀经典文献进行了全面研究。精心汇编以提取个性化饮食调节肠道微生物群的有价值成果。
有多种饮食用于控制血糖水平，尽管人类之间的基因组相似度为99.9%，但它们对转录组或表观基因组的影响也在研究中。然而，微生物组之间只有10%的相似度。阿育吠陀饮食是根据体质给出的，因此也被称为个性化饮食。
阿育吠陀中为T2D规定的饮食富含纤维、多酚和复合碳水化合物，可丰富产生丁酸盐的细菌并减少产生脂多糖的细菌。因此，需要通过丰富有益的肠道微生物群来采用个性化饮食来控制血糖水平。与肠道微生物群相关的个性化饮食方法可能有助于维持T2D患者的血糖水平。
