Department of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus (RHCC), Haifa, Israel.
Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Bioelectromagnetics. 2023 Oct-Dec;44(7-8):144-155. doi: 10.1002/bem.22481. Epub 2023 Sep 1.
Pulsed electromagnetic field (PEMF) therapy modulates the immune response and is successfully used in orthopedics to treat osteoarthritis and improve bone regeneration. This may suggest that this treatment may consequently reduce peri-implant soft tissue inflammation and marginal bone loss. To compare clinical, radiographic, and immunological results following nonsurgical treatment for peri-implantitis with or without PEMF therapy. Patients with peri-implantitis were included: pocket probing depth (PPD) between 6 and 8 mm with bleeding on probing (BOP); crestal bone loss between 3 and 5 mm. A novel healing abutment that contained active (test) or inactive (control) PEMF was connected. PEMF was administered via the abutment at exposure ratio of 1/500-1/5000, intensity: 0.05-0.5 mT, frequency: 10-50 kHz for 30 days. Nonsurgical mechanical implant surface debridement was performed. Patients were examined at baseline, 1 and 3 months. Clinical assessment included: plaque index, BOP, PPD, recession, and bone crest level which was radiography measured. Samples of peri-implant crevicular fluid were taken to analyze interleukin-1β (IL-1β). Twenty-three patients (34 implants; 19 control, 15 test) were included. At the follow-up, mean crestal bone loss was lower in the test group at 1 and 3 months (2.48 mm vs. 3.73 mm, p < 0.05 and 2.39 vs. 3.37, p < 0.01). IL-1β levels were also lower in the test group at 2 weeks (72.86 pg/mL vs. 111.7, p < 0.05). Within all the limitation of this preliminary study, the test group improved clinical parameters after a short-term period compared to the control group.
脉冲电磁场（PEMF）治疗可调节免疫反应，已成功用于骨科治疗骨关节炎和改善骨再生。这可能表明，这种治疗方法可能会减少种植体周围软组织炎症和边缘骨丧失。本研究旨在比较牙周炎非手术治疗中应用和不应用脉冲电磁场治疗的临床、影像学和免疫学结果。纳入牙周炎患者：探诊深度（PPD）在 6 至 8mm 之间，探诊出血（BOP）阳性；牙槽骨嵴顶吸收在 3 至 5mm 之间。连接一种新型愈合基台，其中包含活动（实验组）或不活动（对照组）脉冲电磁场。通过基台以 1/500-1/5000 的暴露比、强度 0.05-0.5mT、频率 10-50kHz 进行 30 天的脉冲电磁场治疗。进行非手术机械性种植体表面清创。患者在基线、1 个月和 3 个月时接受检查。临床评估包括：菌斑指数、BOP、PPD、退缩和用放射线测量的牙槽嵴顶水平。采集种植体周围龈沟液样本分析白细胞介素-1β（IL-1β）。纳入 23 名患者（34 个种植体；19 个对照组，15 个实验组）。在随访时，实验组在第 1 个月和第 3 个月的牙槽骨嵴顶吸收明显低于对照组（2.48mm 比 3.73mm，p<0.05 和 2.39mm 比 3.37mm，p<0.01）。实验组在第 2 周的 IL-1β水平也较低（72.86pg/mL 比 111.7pg/mL，p<0.05）。在这项初步研究的所有限制范围内，实验组在短期治疗后与对照组相比，改善了临床参数。
