Souza João Gabriel S, Azevedo Fabio, Borges Maria Helena Rossy, Costa Raphael Cavalcante, Shiba Takahiko, Barak Shlomo, Mayer Yaniv, Figueiredo Luciene Cristina de, Feres Magda, Barão Valentim A R, Shibli Jamil A
Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, 07023-070, Brazil.
Department of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, 13414-903, Brazil.
NPJ Biofilms Microbiomes. 2025 Feb 26;11(1):36. doi: 10.1038/s41522-025-00667-0.
Dental implant-related infections, which lack effective therapeutic strategies, are considered the primary cause for treatment failure. Pulsed electromagnetic field (PEMF) technology has been introduced as a safe and effective modality for enhancing biological responses. However, the PEMF effect on modulating microbial diversity has not been explored. Thus, we tested a miniaturized PEMF biomedical device as a healing component for dental implants. PEMF activation did not alter the chemical composition, surface roughness, wettability, and electrochemical performance. PEMF effectively controlled chronic in vitro polymicrobial microbial accumulation. The in vivo study where devices were inserted in the patients' oral cavities and 16S RNA sequencing analysis evidenced a fivefold or more reduction in 23 bacterial species for PEMF group and the absence of some species for this group, including pathogens associated with implant-related infections. PEMF altered bacterial interactions and promoted specific bacterial pathways. PEMF has emerged as an effective strategy for controlling implant-related infections.
缺乏有效治疗策略的种植牙相关感染被认为是治疗失败的主要原因。脉冲电磁场（PEMF）技术已作为一种增强生物反应的安全有效方式被引入。然而，PEMF对调节微生物多样性的影响尚未得到探索。因此，我们测试了一种小型化的PEMF生物医学设备作为种植牙的愈合组件。PEMF激活并未改变化学成分、表面粗糙度、润湿性和电化学性能。PEMF有效地控制了体外慢性多微生物的积聚。在体内研究中，将设备植入患者口腔，16S RNA测序分析表明，PEMF组中23种细菌的数量减少了五倍或更多，且该组中一些物种消失，包括与种植牙相关感染有关的病原体。PEMF改变了细菌相互作用并促进了特定的细菌途径。PEMF已成为控制种植牙相关感染的有效策略。
