Brailski Kh, Dimitrov B, Damianov B, Dinkov L, Todorov D
Vutr Boles. 1986;25(4):83-91.
After brief literature data, a clinical case is reported with generalized sarcoidoses with predominant affection of liver and lymph nodes. A detailed clinical-laboratory characteristics is presented and the diagnosis has been histomorphologically objectivized. The hepatocytes were electron-microscopically studied and disorders in carbohydrate metabolism established with predomination of glyconeopoiesis. Bacterial-like structures were established in hepatocytes, providing grounds to look for further possibilities in that aspect for throwing light upon the etiology of sarcoidosis. The clinical case presented confirmed the high diagnostic value of liver biopsy in sarcoidosis, even in the cases with obvious extrahepatal localization of the changes. The therapeutic effect attained confirms, once again, the therapeutic possibilities of the corticosteroids, administered in proper doses.
在简短的文献资料介绍之后，报告了一例以肝脏和淋巴结受累为主的全身性结节病临床病例。呈现了详细的临床实验室特征，并通过组织形态学确诊。对肝细胞进行了电子显微镜研究，确定了碳水化合物代谢紊乱，以糖异生为主。在肝细胞中发现了类似细菌的结构，为在这方面进一步探索以阐明结节病的病因提供了依据。所呈现的临床病例证实了肝活检在结节病诊断中的高价值，即使在病变明显位于肝外的病例中也是如此。所取得的治疗效果再次证实了适当剂量使用皮质类固醇的治疗可能性。
