ANSES, Mycoplasmology, Bacteriology and Antimicrobial Resistance Unit, Ploufragan-Plouzané-Niort Laboratory , Ploufragan, France.
Université de Lorraine, INRAE, DynAMic , Nancy, France.
J Clin Microbiol. 2023 Sep 21;61(9):e0016423. doi: 10.1128/jcm.00164-23. Epub 2023 Sep 1.
an emerging zoonotic pathogen, causes invasive infections and substantial economic losses in the pig industry worldwide. Antimicrobial resistance against 22 antibiotics was studied for 200 . strains collected in different geographical regions of France. Most of the strains (86%) showed resistance to at least one antibiotic with a low rate of resistance to fluoroquinolones, penicillins, pleuromutilin, and diaminopyrimidine-sulfonamides, and a higher rate to macrolides-lincosamides and tetracycline. Multi-resistance patterns were observed in 138 strains; three of them being resistant to six antibiotic families. Statistical analyses highlighted a decrease in the resistance to trimethoprim-sulfamethoxazole, in our collection, between the two periods studied-before 2010 and after 2015-as well as an impact of the geographical origin with a higher rate of resistance to macrolides-lincosamides and penicillin in Brittany than in the other French regions. Furthermore, macrolides-lincosamides and tetracycline resistance patterns were more likely to be found in pig isolates than in human and wild boar isolates. A difference in resistance was also observed between serotypes. Most of the penicillin-resistant strains belong to serotypes 1, 5, 9, 11, 12, 15, 27, and 29. Finally, penicillin and pleuromutilin resistances were mostly found in "non-clinical" isolates. The empirical treatment of human and porcine infections due to in France can therefore still be carried out with beta-lactams. However, this study emphasizes the need to monitor antimicrobial resistance in this zoonotic pathogen.
一种新兴的人畜共患病病原体，在全球范围内导致猪养殖业的侵袭性感染和重大经济损失。对来自法国不同地理区域的 200 株 菌株进行了 22 种抗生素的耐药性研究。大多数菌株（86%）至少对一种抗生素表现出耐药性，对氟喹诺酮类、青霉素类、截短侧耳素和二氨基嘧啶-磺胺类的耐药率较低，对大环内酯类-林可酰胺类和四环素的耐药率较高。在 138 株菌株中观察到多耐药模式；其中 3 株对 6 种抗生素家族耐药。统计分析突出显示，在我们的研究中，2010 年之前和之后两个时期之间，trimethoprim-sulfamethoxazole 的耐药性下降，以及地理起源的影响，布列塔尼的大环内酯类-林可酰胺类和青霉素耐药率高于法国其他地区。此外，猪分离株中更可能发现大环内酯类-林可酰胺类和四环素耐药模式，而不是人分离株和野猪分离株。在血清型之间也观察到耐药性差异。大多数青霉素耐药菌株属于血清型 1、5、9、11、12、15、27 和 29。最后，青霉素和截短侧耳素耐药性主要存在于“非临床”分离株中。因此，在法国，由于 引起的人类和猪感染的经验性治疗仍然可以使用β-内酰胺类药物进行。然而，本研究强调了需要监测这种人畜共患病病原体的抗菌药物耐药性。
