粪便钙卫蛋白作为肠道炎症标志物在青光眼患者中升高。

Fecal calprotectin as an intestinal inflammation marker is elevated in glaucoma.

机构信息

Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science & Technology of China, Chengdu, China.

Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China.

出版信息

Biomark Med. 2023 May;17(9):465-473. doi: 10.2217/bmm-2023-0352. Epub 2023 Sep 1.

DOI:10.2217/bmm-2023-0352

PMID:37656013

Abstract

The aim of this study was to investigate the potential association between glaucoma and fecal calprotectin. A total of 144 glaucomatous patients and 66 healthy controls were enlisted for this study. The fecal calprotectin was assessed using enzyme-linked immunosorbent assay. The median fecal calprotectin levels were significantly elevated in glaucoma (73.67 vs 41.97 μg/g; p < 0.001), primary angle-closure glaucoma (76.85 μg/g; p < 0.001) and primary open-angle glaucoma (69.29 μg/g; p = 0.016) groups compared with controls. A notable proportion of the glaucoma (24%; p < 0.001), primary angle-closure glaucoma (21%; p < 0.001) and primary open-angle glaucoma (24%; p < 0.001) subgroups exhibited highly abnormal fecal calprotectin levels (≥250 μg/g). Elevated fecal calprotectin might indicate potential intestinal inflammation in glaucoma.

摘要

本研究旨在探讨青光眼与粪便钙卫蛋白之间的潜在关联。共纳入 144 例青光眼患者和 66 例健康对照者进行本研究。采用酶联免疫吸附试验检测粪便钙卫蛋白。与对照组相比，青光眼（73.67 与 41.97 μg/g；p < 0.001）、原发性闭角型青光眼（76.85 μg/g；p < 0.001）和原发性开角型青光眼（69.29 μg/g；p = 0.016）患者的粪便钙卫蛋白中位数水平显著升高。青光眼（24%；p < 0.001）、原发性闭角型青光眼（21%；p < 0.001）和原发性开角型青光眼（24%；p < 0.001）亚组中相当一部分患者粪便钙卫蛋白水平显著升高（≥250 μg/g）。粪便钙卫蛋白升高可能提示青光眼存在潜在的肠道炎症。