University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Department of Pediatrics, University of Arizona, Tucson, Arizona.
Pediatrics. 2023 Sep 1;152(Suppl 2). doi: 10.1542/peds.2023-062292E.
Lifelong respiratory health is rooted in the structural and functional development of the respiratory system in early life. Exposures and interventions antenatally through childhood can influence lung development into young adulthood, the life stage with the highest achievable lung function. Because early respiratory health sets the stage for adult lung function trajectories and risk of developing chronic obstructive pulmonary disease, understanding how to promote lung health in children will have far reaching personal and population benefits. To achieve this, it is critical to have accurate and precise measures of structural and functional lung development that track throughout life stages. From this foundation, evaluation of environmental, genetic, metabolic, and immune mechanisms involved in healthy lung development can be investigated. These goals require the involvement of general pediatricians, pediatric subspecialists, patients, and researchers to design and implement studies that are broadly generalizable and applicable to otherwise healthy and chronic disease populations. This National Institutes of Health workshop report details the key gaps and opportunities regarding lung function and structure.
终身呼吸健康源于生命早期呼吸系统的结构和功能发育。在胎儿期到儿童期的各种暴露和干预措施会影响肺部发育到青年期，这是可达到的肺功能最高的生命阶段。由于早期呼吸健康为成年期肺功能轨迹和发展为慢性阻塞性肺疾病的风险奠定了基础，因此了解如何促进儿童的肺部健康将具有深远的个人和人群效益。为了实现这一目标，必须要有准确和精确的衡量结构和功能肺发育的方法，这些方法要能贯穿整个生命阶段。在此基础上，可以评估涉及健康肺发育的环境、遗传、代谢和免疫机制。这些目标需要普通儿科医生、儿科专家、患者和研究人员的参与，以设计和实施广泛适用且适用于其他健康和慢性疾病人群的研究。美国国立卫生研究院的这份研讨会报告详细说明了有关肺功能和结构的关键差距和机遇。
