Hautke Alexander, Ebbinghaus Simon
Institut für Physikalische und Theoretische Chemie, TU Braunschweig, Rebenring 56, D-38106 Braunschweig, Germany.
Lehrstuhl für Biophysikalische Chemie and Research Center Chemical Sciences and Sustainability, Ruhr-Universität Bochum, D-44780 Bochum, Germany.
Biol Chem. 2023 Sep 4;404(10):897-908. doi: 10.1515/hsz-2023-0202. Print 2023 Sep 26.
ATP is an important small molecule that appears at outstandingly high concentration within the cellular medium. Apart from its use as a source of energy and a metabolite, there is increasing evidence for important functions as a cosolute for biomolecular processes. Owned to its solubilizing kosmotropic triphosphate and hydrophobic adenine moieties, ATP is a versatile cosolute that can interact with biomolecules in various ways. We here use three models to categorize these interactions and apply them to review recent studies. We focus on the impact of ATP on biomolecular solubility, folding stability and phase transitions. This leads us to possible implications and therapeutic interventions in neurodegenerative diseases.
三磷酸腺苷（ATP）是一种重要的小分子，在细胞介质中以极高的浓度存在。除了用作能量来源和代谢物外，越来越多的证据表明它作为生物分子过程的共溶质具有重要功能。由于其具有增溶的促离子键合三磷酸基团和疏水的腺嘌呤部分，ATP是一种多功能共溶质，能够以多种方式与生物分子相互作用。我们在此使用三种模型对这些相互作用进行分类，并应用它们来回顾近期的研究。我们重点关注ATP对生物分子溶解度、折叠稳定性和相变的影响。这使我们探讨其在神经退行性疾病中的潜在意义和治疗干预措施。
