Rehabilitation Sciences Post-Graduation Programme, Augusto Motta University Centre (UNISUAM), Rio de Janeiro, Brazil.
Faculty of Physiotherapy, Augusto Motta University Centre (UNISUAM), Rio de Janeiro, Brazil.
PLoS One. 2023 Sep 1;18(9):e0290850. doi: 10.1371/journal.pone.0290850. eCollection 2023.
Post-tuberculosis bronchiectasis (PTBB) is gaining recognition as an important chronic lung disease, representing a neglected condition with a significant burden for the individual. Recently, the Glittre-ADL test (TGlittre) has been proposed for the assessment of functional capacity, which incorporates tasks of daily living demanding the upper and lower extremities. This study used TGlittre to compare patients with PTBB to patients with non-post-tuberculosis bronchiectasis (NPTBB) and evaluate the determinants of performance during TGlittre.
This is a cross-sectional study in which 32 patients with PTBB and 29 with NPTBB underwent TGlittre. In addition, they completed Short Form-36 (SF-36), handgrip strength, quadriceps muscle strength (QMS) and pulmonary function tests (PFTs).
Both PTBB and NPTBB required much more time to perform the TGlittre compared to the predicted values, although they did not differ statistically from each other [152 (124-200) vs. 145 (117-179)% predicted, p = 0.41]. Regarding the PFTs, the PTBB participants showed significantly lower values than the NPTBB participants in forced vital capacity (FVC, 60 ± 14.5 vs. 78.2 ± 22.2% predicted, p<0.001) and total lung capacity [82 (66-95) vs. 93 (82-105)% predicted, p = 0.028]. In the PTBB group, FVC (p<0.001) and QMS (p = 0.001) were the only significant independent variables to predict TGlittre time, explaining 71% of the variability in TGlittre time. In the NPTBB group, maximal expiratory pressure (p = 0.002), residual volume/TLC (p = 0.001) and QMS (p = 0.032) were the significant independent variables for predicting TGlittre time, explaining 73% of the variability in TGlittre time.
PTBB patients have lower than expected performance on TGlittre, though similar to NPTBB patients. The PTBB patients had a greater reduction in lung volume than NPTBB patients. Furthermore, the performance on TGlittre in PTBB patients is largely explained by lung volume and QMS.
肺结核后支气管扩张症（PTBB）作为一种重要的慢性肺部疾病正逐渐受到关注，它代表了一种被忽视的疾病，给个人带来了沉重的负担。最近，Glittre-ADL 测试（TGlittre）已被提出用于评估功能能力，其中包含了需要上肢和下肢活动的日常生活任务。本研究使用 TGlittre 比较了 PTBB 患者与非肺结核后支气管扩张症（NPTBB）患者，并评估了 TGlittre 期间表现的决定因素。
这是一项横断面研究，纳入了 32 名 PTBB 患者和 29 名 NPTBB 患者进行 TGlittre 测试。此外，他们还完成了 36 项简短健康调查（SF-36）、握力、股四头肌力量（QMS）和肺功能测试（PFTs）。
PTBB 和 NPTBB 患者完成 TGlittre 测试所需的时间均明显长于预测值，但彼此之间无统计学差异[152（124-200）% 预测值比 145（117-179）% 预测值，p=0.41]。在 PFTs 方面，PTBB 患者的用力肺活量（FVC）明显低于 NPTBB 患者[60±14.5 比 78.2±22.2% 预测值，p<0.001]，总肺容量也更低[82（66-95）比 93（82-105）% 预测值，p=0.028]。在 PTBB 组中，FVC（p<0.001）和 QMS（p=0.001）是唯一能够显著预测 TGlittre 时间的独立变量，解释了 TGlittre 时间变异性的 71%。在 NPTBB 组中，最大呼气压力（p=0.002）、残气量/TLC（p=0.001）和 QMS（p=0.032）是预测 TGlittre 时间的显著独立变量，解释了 TGlittre 时间变异性的 73%。
PTBB 患者在 TGlittre 上的表现低于预期，但与 NPTBB 患者相似。PTBB 患者的肺容积下降幅度大于 NPTBB 患者。此外，PTBB 患者在 TGlittre 上的表现主要由肺容积和 QMS 解释。
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