Division of Oculofacial Plastic and Reconstructive Surgery, Viterbi Family Department of Ophthalmology, Shiley Eye Institute, UC San Diego, La Jolla, CA, U.S.A.
Division of Pediatric Ophthalmology and Adult Strabismus, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, U.S.A.
Ophthalmic Plast Reconstr Surg. 2023;39(6):e208-e210. doi: 10.1097/IOP.0000000000002482. Epub 2023 Sep 1.
The authors report 4 cases of cutaneous hypersensitivity reactions developing in the course of teprotumumab treatment for thyroid eye disease. The onset of the cutaneous hypersensitivity reaction was also observed during the treatment course in all cases, between the second and fifth infusions. Teprotumumab-related cutaneous reactions suggest a possible immunogenic component of the monoclonal antibody and highlight the importance of close monitoring during treatment.
作者报告了 4 例在使用替普妥单抗治疗甲状腺眼病过程中出现的皮肤过敏反应。所有病例均在第二次至第五次输注期间观察到皮肤过敏反应的发生。与替普妥单抗相关的皮肤反应提示该单克隆抗体可能具有免疫原性成分，并强调了在治疗期间密切监测的重要性。
