Jin Haoyi, Liu Xi, Liu Hong-Xu
Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, 110042, Liaoning, China.
Department of Urology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, 110042, Liaoning, China.
Biochim Biophys Acta Rev Cancer. 2023 Nov;1878(6):188970. doi: 10.1016/j.bbcan.2023.188970. Epub 2023 Aug 30.
Studies examining the regulatory roles and clinical applications of monosaccharides other than glucose in cancer have been neglected. Mannose, a common type of monosaccharide found in human body fluids and tissues, primarily functions in protein glycosylation rather than carbohydrate metabolism. Recent research has demonstrated direct anticancer effects of mannose in vitro and in vivo. Simply supplementing cell culture medium or drinking water with mannose achieved these effects. Moreover, mannose enhances the effectiveness of current cancer treatments including chemotherapy, radiotherapy, targeted therapy, and immune therapy. Besides the advancements in basic research on the anticancer effects of mannose, recent studies have reported its application as a biomarker for cancer or in the delivery of anticancer drugs using mannose-modified drug delivery systems. This review discusses the progress made in understanding the regulatory roles of mannose in cancer progression, the mechanisms underlying its anticancer effects, and its current application in cancer diagnosis and treatment.
研究葡萄糖以外的单糖在癌症中的调节作用和临床应用的工作一直被忽视。甘露糖是一种在人体体液和组织中常见的单糖类型，主要在蛋白质糖基化过程中发挥作用，而非碳水化合物代谢。最近的研究已经证明了甘露糖在体外和体内具有直接的抗癌作用。通过在细胞培养基或饮用水中简单添加甘露糖就能实现这些效果。此外，甘露糖能增强当前癌症治疗方法（包括化疗、放疗、靶向治疗和免疫治疗）的疗效。除了甘露糖抗癌作用基础研究的进展外，最近的研究还报道了其作为癌症生物标志物的应用，或利用甘露糖修饰的药物递送系统进行抗癌药物递送。这篇综述讨论了在理解甘露糖在癌症进展中的调节作用、其抗癌作用的潜在机制以及其在癌症诊断和治疗中的当前应用方面所取得的进展。
