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甘露糖:药物治疗中的优秀参与者和辅助剂。

Mannose: Good player and assister in pharmacotherapy.

机构信息

Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, Guangdong Medical University, Zhanjiang, China; Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Pharmaceutical Science, Guangdong Medical University, Zhanjiang, China.

Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, Guangdong Medical University, Zhanjiang, China; Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Pharmaceutical Science, Guangdong Medical University, Zhanjiang, China.

出版信息

Biomed Pharmacother. 2020 Sep;129:110420. doi: 10.1016/j.biopha.2020.110420. Epub 2020 Jun 18.

Abstract

Mannose is a monosaccharide widely distributed in body fluids and tissues, especially in the nerve, skin, testicles, retina, liver and intestines. It is used to synthesize glycoproteins and participate in immune regulation. In recent years, mannose has been applied more and more widely in the biomedical context as people have a deeper understanding of its biological effects. This review introduces the use of mannose in treating various diseases (including cancer, urinary tract infections, type 1 diabetes, and diabetic wounds), preventing pancreatic fistula, and improving magnetic resonance imaging for acute pancreatitis. We also demonstrate that mannose has the potential for clinical applications.

摘要

甘露糖是一种广泛分布于体液和组织中的单糖,尤其存在于神经、皮肤、睾丸、视网膜、肝脏和肠道中。它被用于合成糖蛋白并参与免疫调节。近年来,随着人们对其生物学作用的认识不断深入,甘露糖在生物医学领域的应用越来越广泛。本文介绍了甘露糖在治疗各种疾病(包括癌症、尿路感染、1 型糖尿病和糖尿病性伤口)、预防胰瘘以及改善急性胰腺炎的磁共振成像等方面的应用。我们还证明了甘露糖具有临床应用的潜力。

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